Flashcards in Overview of Renal Structure and Function Deck (18):
Na+ is restricted to (intracellular or extracellular space)
What determines the size of the extracellular fluid volume (ECFV)?
Total body Na content
The ECFV determines ...
BP and blood volume
What determines osmolality?
How does an inc in total body Na affect the kidneys? (what are the chain of event this sets off?)
Na inc causes and inc in osmolarity --> stimulates thirst
Inc water intake stimulates secretion of vasopressin --> tells the kidneys to conserve water
What determines the size of total body water?
What % of the male body is water? female?
* diff due to lower skeletal muscle mass
What is the major buffer of the ECFV?
What is the normal pH of blood ?
What minerals does the kidney maintain homeostasis for?
Ca, phosphorus, and Mg
What waste material does the kidney get rid of?
urea (from protein metabolism)
creatinine (from muscle metabolism)
uric acid (from breakdown of nucleic acids)
What are the endocrine functions of the kidney?
2. active form Vit D/calcitrol (1, 25 (OH)2D3)
5. prostaglandins (esp PGI2, PGE2)
6. endothelial factor (NO, endothelin)
PGI2 and PGE2 vasocontrict or vasodilate?
Endothelin vasocontrict or vasodilate?
Specifically what/where in the kidney makes renin?
juxtaglomerular apparatus in the afferent arteriole
What is renin?
catalytic enzyme that starts off the angiotensin-aldosterone cascade
What are the 3 ways the kidney controls BP?
1. homeostasis of Na, H2O, ECFV
2. control of renin-angiotensin-aldosterone axis
3. production of vasodilatory substances