Overview of Renal Structure and Function Flashcards Preview

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Flashcards in Overview of Renal Structure and Function Deck (18):
1

Na+ is restricted to (intracellular or extracellular space)

extracellular space

2

What determines the size of the extracellular fluid volume (ECFV)?

Total body Na content

3

The ECFV determines ...

BP and blood volume

4

What determines osmolality?

Na

5

How does an inc in total body Na affect the kidneys? (what are the chain of event this sets off?)

Na inc causes and inc in osmolarity --> stimulates thirst
Inc water intake stimulates secretion of vasopressin --> tells the kidneys to conserve water

6

What determines the size of total body water?

Na

7

What % of the male body is water? female?

males: 60%
females: 50%
* diff due to lower skeletal muscle mass

8

What is the major buffer of the ECFV?

bicarbonate

9

What is the normal pH of blood ?

7.4

10

What minerals does the kidney maintain homeostasis for?

Ca, phosphorus, and Mg

11

What waste material does the kidney get rid of?

urea (from protein metabolism)
creatinine (from muscle metabolism)
uric acid (from breakdown of nucleic acids)

12

What are the endocrine functions of the kidney?

production of
1. EPO
2. active form Vit D/calcitrol (1, 25 (OH)2D3)
3. Renin
4. Bradykinin
5. prostaglandins (esp PGI2, PGE2)
6. endothelial factor (NO, endothelin)

13

PGI2 and PGE2 vasocontrict or vasodilate?

vasodilate

14

Endothelin vasocontrict or vasodilate?

vasoconstrict

15

Specifically what/where in the kidney makes renin?

juxtaglomerular apparatus in the afferent arteriole

16

What is renin?

catalytic enzyme that starts off the angiotensin-aldosterone cascade

17

What are the 3 ways the kidney controls BP?

1. homeostasis of Na, H2O, ECFV
2. control of renin-angiotensin-aldosterone axis
3. production of vasodilatory substances

18

What is the renin-angiotensin-aldosterone axis and what is the kidney's role with it?

-regulates BP
-Kidney makes renin which sets off cascade -->
Angiotensin II is a potent vasocontrictor. Aldosterone promotes Na reabs