(P4) Resp Patho: Interstitial pneumonia

Question 1

Identify:

Answer 1

Interstitial pneumonia

1. Most common cause is viral infection of the lung by viruses (CMV, Varicella, HSV)
2. septa
   * 3. hyaline membranes**

Question 2

Identify:

This lesion can be complicated by?

Answer 2

INTERSTITIAL PNEUMONIA

-Can be complicated by HYALINE MEMBRANES

Question 3

Identify this lesion

What is the most common cause?

(name all that apply)

Answer 3

Interstitial pneumonia

• The most common cause is viral infection of the lung
• CMV, varicella, Herpes simplex virus (HSV)
• Viruses affect the alveolar epithelium and cause mononuclear infiltration*

Question 4

Identify lesion:

Who is most affected by this lesion

and what are the syptoms?

Answer 4

Interstitial pneumonia

Children, elderly patients

• -Often asymptomatic, no changes in x-ray*
• • Dilated interstitial parts of the lung, airspaces preserved*

Symptoms:

• ▪ Long-term cough*
• ▪ Reduced lung capacity*

Question 5

identify lesion:

What is its Morphology?

Answer 5

Interstitial pneumonia

Necrosis of type 1 epithelial cells and hyaline membrane formation

(Type 1 – most sensitive to damage and loss of integrity (intra-alveolar)

Morphology:

• • No circumscribed changes.*
• -More yellow areas suspected (in autopsy sample). Newborn might die from interstitial pneumonia*

Question 6

Identify

and

provide Microscopy of this slide:

Answer 6

Interstitial pneumonia

• -Thickened septa containing cells (inflammatory cells – lymphocytes, plasma cells)
• Dilated capillaries.*
• -Hyaline membrane covers septa wall (from necrotic debris of injured cells).*
• -Can cause death when large areas covered*
• • Bronchi normal with no infiltration*

Question 7

Identify slide:

Give 4 examples:

Answer 7

Interstitial pneumonia

Type 1 – most sensitive to damage and loss of integrity (intra-alveolar)

4 types:

1. Mycoplasma pneumonia
2. Viral pneumonia
3. Rickettsia pneumonia
4. Ornithosis (psittacosis)

Question 8

Identify

Answer 8

Question 9

identify:

Answer 9

Interstitial pneumonia