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Pharmacology Unit 6 > P450 Examples > Flashcards

Flashcards in P450 Examples Deck (6)
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1

From the lecture, what drug class interferes with ACEIs for hypertension?

NSAIDs, causing more limited effect; NSAIDs have similar efefct on thiazides

2

From the lecture, what drug class interferes with itraconazole for onchomycosis? What is the mechanism?

Prilosec/PPIs
Decreased substrate bioavailability

3

From the lecture, what drug class interferes with amlodipine for hypertension? What is the mechanism?

Antituberculars (Rifampin)
P450 induction increasing clearance

4

From the lecture, what drug class interferes with warfarin for DVT treatment post-valproate use? What is the mechanism?

Carbamazepine (carboxamide antiepileptic)
Increased clearance

5

What common drugs can cause 3rd degree AV block when using metoprolol? What is the mechanism?

Acetaminophen and Paroxetine
Decreased clearance due to P450 inhibition

6

What antidepressant is a potent P450 inducer when codeine is administered?

Paroxetine