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Flashcards in Pain tx 2 Deck (23):
1

___________ and meperidine can have a severe tx involving excitation, delirium, hyperpyrexia, convulsions, and respiratory depression

MAOI

2

80X more potent than morphine. IV administration for pre and post surgery analgesia. Rapid onset and short duration

Fentanyl

3

6000X more potent than morphine. Fentanyl derivative

Sufentanil

4

Remifentanil is a ______________ acting fentanyl derivative

short

5

Less potent than morphine. Component of cough syrup

codeine

6

Precursor for krokodil

codeine

7

Slow CYP2D6 metabolizers of codeine

not effective pain relief

8

Fast CYP2D6 metabolizers of codeine

Fast conversion to morphine, OD potential

9

Propoxyphene is a ______ agonist with ______ potency

mu
weak

10

_______ now included in Talwin to prevent drug abuse

Naloxone

11

Absorbed sublingually. Used in pregnant addicts. Partial agonist at mu receptors and antagonist at kappa receptors

buprenorphine

12

Inhibits NE and serotonin reuptake. Used in chronic and back pain. Given to dogs for pain relief

Tramadol

13

Suppresses response of cough center. Less constipation. Not antagonized by naloxone

dextromethorphan

14

Used in robotripping with robitussin

dextromethorphan

15

Clonidine is an ____ agonist. Inhibits pain by activating these receptors in the ___________

alpha 2
dorsal horn

16

Venlafaxine and duloxetine are

SNRI's

17

TCAs ___ NE in ________ synapses. Can increase suicidal thoughts

increase
dorsal horn

18

TCA and SNRIs work by inhibiting _____ reuptake

NE and serotonin

May also work on experience of pain

19

alpha 2 delta ligands (gabapentin and pregabalin), carbamazepine are

antiepileptics

20

Antiepileptics ________ membrane to block action potential by blocking channels

hyperpolarize

21

alpha2delta ligands ________ activation of N and Ca channels

reduce

22

Stabilizes inactive voltage gated na channel

carbamazepine

23

Excitement caused at toxic doses, acts as a CNS stimulant.

Meperidine