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Flashcards in Pain tx Deck (41):
1

Opioids work via ____________ receptors

G protein coupled

2

Most important opioid receptors are

mu and kappa

3

Opioids work by ___ K channels, and inhibiting _____ channels and _______

activation
ca
adenyl cyclase

4

Mu receptor involved in

respiratory depression

5

Endomorphines, enkaphalins, and endorphins are endogenous agonists of

mu receptor

6

naloxone and naltrexone are antagonists of ________ receptor

mu

7

Morphine, fentanyl, methadone, meperidine, and buprenorphine are agonists of

mu receptor

8

Dynorphins are endogenous agonists of

kappa receptor

9

Butorphanol, pentazocine, and nalbuphine are agonists of

kappa receptor

10

Opioids are classified based on

strength

11

Fentanyl, morphine, methadone, heroin, and oxycodone are _____ agonists with ______ addiction potential

strong
high

12

Analgesia
Controlled withdrawal from opioids

methadone

13

Analgesic and anti-tussive
moderate agonist

codeine

14

Buprenorphine, pentazocine, butorphanol, and nalbuphine are

mixed agonists/antagonists

15

used for opioid withdrawal, detox, and maintenace

buprenorphine

16

Used in opioid OD

naloxone

17

Used in opioid detox and alcoholism

naltrexone

18

Gold standard opioid

morphine

19

______ contains morphine, codeine, and papaverine

opium

20

Acts at mu receptors with high affinity and kappa receptors in spinal cord. Analgesia w/o LOC

morphine

21

Promotes euphoria and dysphoria which promotes substance abuse
Causes nausea and vomiting by action on _______

Morphine
CTZ

22

Use ___________ to dx opioid OD

miosis

23

Opioids cause major major

constipation

24

Diphenoxylate and loperamide are _________ opioids with no CNS activity

antidiarrheal

25

A lot or few drug interactions with opioids?

A lot

26

Opioid poisoning?

Ventilation and give naloxone

27

Morphine also has antitussive effects in the

medulla

28

Used for cough suppression

codeine, hydrocodone

29

Target inflammatory components of pain cascade.

non-opioid analgesics

30

Both heroine and codeine are precursors of

morphine

31

CYP2D6 changes __________ to morphine

codeine

32

7X more potent that oral morphine. Used for severe pain. Less active metabolites

Hydromorphone

33

Constipation and biliary spasms are main side effects

methadone

34

Long half life of 1 to 1.5 days. Tolerance develops slowly. Major OD issue in Appalachia

Methadone

35

Methadone lacks _________ activity so tolerance doesn't develop as quickly and there's less side effects

kappa

36

Fastest and biggest high

heroin

37

Acts slowest and longest

methadone

38

Diacetylmorphine and 6-monoacetylmorphine have ____________ BBB penetration than morphine

higher

39

Hydrocodone and acetominophen is ________ to morphine

orally equivalent

40

New extended release form of ______ has major abuse and OD potential

hydrocodone

41

_________ is delayed release form of oxycodone that has large potential for abuse

oxycontin