Pancreas Flashcards by Ricardo Ferral

Q

Alpha cells secrete?

A

Glucagon!

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Delta cells secrete?

A

Somatostatin!

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Proinsulin splits into the following 2 enzymes ?

A

Insulin

3. C-peptide

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Second messenger involved in insulin receptor ?

A

Tyrosine kinase

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

How is glucose taken up by tissues ?

A

Facilitated transport.

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are some insulin-dependent tissues?

A

Adipose tissue
Muscle (resting)
Liver

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are some insulin INDEPENDENT tissues?

A

Brain
RBC
Intestine
Kidney
Liver?
Placenta
Sperm

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Is insulin a catabolic or anabolic hormone?

A

Anabolic (⬆️protein synthesis)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Insulin effect on carbohydrates?

A

⬇️Glucose levels

2. Glycogensis ⬆️

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Insulin effect on protein metabolism ?

A

⬆️Protein synthesis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Insulin effect on lipid metabolism?

A

⬇️Lipolysis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Insulin effect on K+ levels?

A

⬆️Na+K+ ATPase

2. ⬇️K+ levels

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

How are ATP-K+ gated channels closed?

A

Glucose enters the cell
⬆️Glycolysis
⬆️ATP
⬆️Intracellular K+
Depolarization
⬆️Voltage Gated Ca+ channels
⬆️Ca+ levels
⬆️ Insulin Exocitosis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Mechanism of action of Sulfonylureas?

A

Block ATP-sensitive K+ Channels

2. ⬆️ Insulin release!!

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Name the Incretins?

A

Glucagon-Like Peptide (GLP)

2. Glucose Insulinotropic Peptide (GIP)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Primary site of action of glucagon ?

Study These Flashcards

A

Liver

Q

Glycogen action in Carbohydrates, Lipids and Proteins?

Study These Flashcards

A

CH: glycogenolysis, gluconeogenesis.
Lipids: Lipolysis
Ketogenesis
Proteolysis: ⬆️Urea

Q

Factors that inhibit Glucagon ?

Study These Flashcards

A

Hyperglycemia
Somatostatin
Insulin

Q

Factors that Stimulate Glucagon release?

Study These Flashcards

A

HYPOGLYCEMIA

2. Amino acids (⬆️rich protein meals)

Q

Factors that inhibit insulin ?

Study These Flashcards

A

⬆️Alpha-1 sympathetic

2. Somatostatin

Q

Main Glucose transporter in muscular and adipose tissue?

Study These Flashcards

A

GLUT-4