Pancreas II: CF, Cystic Disorders and Cancer Flashcards
What are the main symptoms of CF?
lung infections, chronic pancreatitis, hypertonic sweat
What is the gene defect in CF
caused by a threebase pair deletion deltaF508 that affects the folding, processing and functioning of the CF gene product, the cystic fibrosis transmembrane conductance regulator.
Explain the pathophys of CF
defective chloride secretion
inspissated secretory product
obstruction of ducts and lumens
infetion, inflammation and tissue destruction
What are clinical manifestations of CF
obstructive/inflammatory lung dz chronic pancreatitis hypertonic sweat ( because no reabso of cl) hepatobiliary tract dz meconium ileus in infants infertility
What can be seen of ducts on histo in CF
several distended with dark pink secretions
What are clinical symptoms of CF
frequent pulmonary infections (pseudomonas)
diarrhea, malabsortion, failure to thrive bc no acinar cells
frequent episodes of dehydration
What are benign pancreatic cysts
pseudocysts
rare non-neoplastic cysts
What are cystic neoplasms of pancreas
serous cystic tumors
mucinous cyst neoplasms
intraductal papillary mucinous neoplasms
solid pesudopapillary neoplams
what are potentially malignant cystic lesions
mucinous cystic neoplasms
intraductal papillary mucinous neoplasms
solid pseudopapillary neoplasms
What type are the majority of pancreatic cancers?
adenocarcinomas of ductal origin
what are the common presentations of pancreatic cancer?
adb pain and weight loss
What is it called when pancreatic cancer results in the lack of gland formation
anaplasia
what are risk factors for pancreatic cancer
cigarette smoking
alcohol in setting of CP
hereditary pancreatitis
family hx
What are clinical features of pancreatic adenocarcinoma?
weight loss, abdominal pain and jaundice (from cbd obstruction)
What is a serum marker elevated in pancreatic adenocarcinomas?
CA19-9
