PANNICULITIS AND CUTANEOUS VASCULITIS

Question 1

The pathology in A is mostly where? Septa or Lobules?

Answer 1

SEPTA

Question 2

Answer 2

Erythema Nodosum

• Mostly SEPTAL inflammation
• May have superficial and deep perivascular inflammation

Question 3

Identify. What condition is this seen?

Answer 3

Miescher’s Granuloma: Histiocytes arranged radially around a stellate or banana-shaped cleft or multinucleate giant cells with a similar cleft

Erythema Nodosum

Question 4

Answer 4

Subcutaneous Fat Necrosis of the Newborn

• Adipocyte cytoplasm becomes eosinophilic
• Needle-shaped clefts arranged radially either replacing the adipocyte or within multinucleated giant cells.

Question 5

CLOSE HISTOLOGIC DIFFERENTIAL OF Subcutaneous Fat Necrosis of the Newborn

Answer 5

Sclerema Neonatorum

Question 6

Differentiate Vasculitis vs Vasculopathy

Answer 6

Question 7

give examples of small vessel vasculitis

Answer 7

Question 8

Give examples of medium vessel vasculitis

Answer 8

Question 9

Give examples of large vessel arteritis

Answer 9

Question 10

Diagnosis? What are the 4 important histologic features?

Answer 10

Leukocytoclastic vasculitis

1) Neutrophils

2) Neutrophilic nuclear dust (karyorrhexis) (Leukocytoclasia)

3) Extravasated erythrocytes

4) Fibrinoid necrosis

Question 11

IMPORTANT HISTOLOGIC FEATURE of leukocytoclastic vasculitis

Answer 11

Fibrin deposition / fibrinoid necrosis

Question 12

Answer 12

Granuloma faciale

Question 13

Answer 13

Erythema elevatum diutinum

Question 14

Answer 14

Medium-vessel VASCULITIS: Polyarteritis Nodosa (PAN)

• Medium-sized arteritis on deep dermis or subcutaneous area