Flashcards in Parasites 1 Deck (74):
Are protozoa intra or extra cellular?
How many cells do protozoa have?
How are most protozoa spread?
Which protozoa can be spread by bites?
Protozoa that enter through the skin?
Tissue destruction due to what in Protozoa?
Invasion of the host tissues by the organism, not host responses against the organism.
Most important strain of Malaria?
What is released into blood with bite of mosquito?
Where do sporozoites go?
Where do Merozoites bind?
Sialic residues on RBCs
How do merozoites detoxify heme?
Form paracrystalline precipitate
Which step in Malaria is inhibited by chloroquine?
Detoxification of heme
Which HLA confers some immunity to malaria?
In malaria hemolysis of infected RBCs leads to what?
Hemoglobinuria (black water fever)
Free hemoglobin results in pigmentation of which cells in particular in Malaria?
What are some of the severe signs that falciparum can cause?
What causes the cerebral involvement in Malaria?
Parasite binds to endothelial cells in brain (schizonts to ICAM-1)
What does vivid and oval infect?
What does plasmodium malarian infect?
Can persist 40 years
What happens to the spleen during chronic infection?
Within RBC merozoites matures into whaT?
Trophozoites in RBC mature into what?
Schizont form and display knobs on surface
Falciparum schizont knobs express sequestering that bind what?
ICAM1, thrombospondin receptor and CD46
Malarial like disease in US?
What transmits Babesiosis?
Fever and hemolytic anemia
What do Trypanosomiasis cause?
African Sleeping sickness
What does African Sleeping sickness cause through proliferation of kinetopastid forms in erythrocytes
Fever, lymphadenopathy, Splenomegaly, brain dysfunction, cachexia, and death
What transmits African Sleeping?
What is Winterbottom's sign?
Winter bottom's sign precedes what?
CNS symptoms of African Sleeping Sickness
IFN gamma stimulates what in ASS?
What causes tissue destruction in ASS?
Ag-Ab complex deposition and release of lysosomal enzymes form degenerating phagocytes
In ASS what forms at site of insect bite?
Large red rubbery chancre (ulcer plus large mononuclear inflammatory infiltrate)
Most frequent cause of heart failure in Brazil/Latin America?
What transmits CD?
What is found at site of entry for CD?
What does CD infect?
What does CD penetrate into?
Skeletal muscel, smooth muscel, and cardiac muscle
Acute CD mainly affects what?
Chronic CD affects what?
Myocardial cells, nerve cells, lymphocytes
4 GI Protozoa?
Infectious form of Entamoeba does what?
Resists gastric acid
What are Entamoeba supposed to look like?
Where is Entamoeba?
Cecum and ascending bowel
Most prevalent pathogenic intestinal organism worldwide?
How do you clean water of Giardia?
Giardia associated with what deficiency?
What type of Giardia is infectious?
Where do trophozoites of Giardia multiply?
What causes Giardia diarrhea?
Nutrient malabsorption by blocking mucosal surface or damaging microvilli
What does Cryptosporidium do>
Diarrhea in children, severe disease in immunosuppressed
How do you get rid of Cryptosporidium?
Cryptosporidia adhere where?
Apical brush border
Invasion and disruption of mucosa cause what in Cryptosporidium?
Malabsorption and secretory diarrhea
Cryptospordium infects what?
Macrophages and underlying Peyer's patches
Control of Crypto is done by what?
CD4 mediated T-cell immunity
Disseminated diseases in immunosuppresed individuals
Crypto and Toxo
Toxoplasmosis is what?
Obligate intracellular protozoan
What types of cells can Toxo infect?
How does Toxo bind to host cells?
Toxo infection controlled by
T-cell mediated immune response
Toxo cysts contain what remain dormant for years?
Toxo worst in which trimester?
What vector gives Leishmaniasis?
what phagocytoses Leishmaniae?
What are Leishmaniar resistant to?
3 Forms of Leishmaniasis?
How does host response affect Leish?
Cellular immune response results in granulomas, anorexic hosts have widespread disease
Which form of Leish gets you black fever?
Which form of Leish gets you foamy macrophages?
Rare diffuse cutaneous
Tissue invaders through water transmission enter through where?
Tissue invaders through nasal mucosa alter what?
Sense of taste and smell