Flashcards in Parkinson/Alzheimer Drugs Deck (15):
Parkinson Disease can be treated with?
Levodopa (with carbidopa)
Selegiline (and COMT inhibitors)
Bromocriptine, Pramipexole and Ropinirole MOA?
Amantadine MOA? Use?
Increases dopamine release and decreases dopamine reuptake
Net: Increase Dopamine
Use: Parkinson and influenza A and rubella
livedo reticularis-lace-like purplish discoloration of the skin
Cocktail to increase L-DOPA
Carbidopa+Levodopa (l-dopa)+Entacapone+ tolcapone
Purpose of Carbidopa, Entacapone+ tolcapone
Carbidopa=>blocks peripheral conversion of l-DOPA
to dopamine by inhibiting DOPA decarboxylase
Entacapone, tolcapone—prevent peripheral l-dopa degradation to 3-O-methyldopa (3-OMD) by inhibiting COMT
Which antimuscarinic can be used to stop the tremor and rigidity in parkinson patients?
Park your Mercedes-Benz.
Levadopa is what kind of an inhibitor? What will it do to Km and Vmax?
Vmax will decrease
MOA: Selectively inhibits MAO-B
Dyskinesia following administration (“on-off” phenomenon)
Why doesn't Selegiline cause Hypertensive crisis?
B/c tyramine is not consumed by MAOb
MOA: NMDA receptor antagonist; helps prevent excitotoxicity (mediated by Ca2+).
Drugs to Treat Alzheimer's Disease? what class of drugs are they?
Grandma Doesn't Remember me Today
Donepezil, galantamine, rivastigmine, tacrine
What drugs can be used for Huntington and their MOA?
Tetrabenazine and reserpine—inhibit vesicular monoamine transporter (VMAT); limit dopamine vesicle packaging and release.
Haloperidol—D2 receptor antagonist.