Parkinson/Alzheimer Drugs Flashcards Preview

Neurology > Parkinson/Alzheimer Drugs > Flashcards

Flashcards in Parkinson/Alzheimer Drugs Deck (15):
1

Parkinson Disease can be treated with?

BALSA:
Bromocriptine
Amantadine
Levodopa (with carbidopa)
Selegiline (and COMT inhibitors)
Antimuscarinics

2

Bromocriptine, Pramipexole and Ropinirole MOA?

Dopamine agonists

3

Amantadine MOA? Use?

Increases dopamine release and decreases dopamine reuptake
Net: Increase Dopamine

Use: Parkinson and influenza A and rubella

4

Amantadine AE?

livedo reticularis-lace-like purplish discoloration of the skin

5

Cocktail to increase L-DOPA

Carbidopa+Levodopa (l-dopa)+Entacapone+ tolcapone

6

Purpose of Carbidopa, Entacapone+ tolcapone

Carbidopa=>blocks peripheral conversion of l-DOPA
to dopamine by inhibiting DOPA decarboxylase

Entacapone, tolcapone—prevent peripheral l-dopa degradation to 3-O-methyldopa (3-OMD) by inhibiting COMT

7

Which antimuscarinic can be used to stop the tremor and rigidity in parkinson patients?

Park your Mercedes-Benz.
Benztropine

8

Levadopa is what kind of an inhibitor? What will it do to Km and Vmax?

Noncomp. inhibitor
Vmax will decrease

9

Selegiline MOA?

MOA: Selectively inhibits MAO-B

10

Levadopa AE?

Dyskinesia following administration (“on-off” phenomenon)

11

Why doesn't Selegiline cause Hypertensive crisis?

B/c tyramine is not consumed by MAOb

12

Memantidine MOA?

MOA: NMDA receptor antagonist; helps prevent excitotoxicity (mediated by Ca2+).

13

Drugs to Treat Alzheimer's Disease? what class of drugs are they?

Grandma Doesn't Remember me Today
Donepezil, galantamine, rivastigmine, tacrine
AChE inhibitors.

14

What drugs can be used for Huntington and their MOA?

Tetrabenazine and reserpine—inhibit vesicular monoamine transporter (VMAT); limit dopamine vesicle packaging and release.
ƒ
Haloperidol—D2 receptor antagonist.

15

Triptans MOA and Use?

MOA: 5-HT1B/1D agonists=> vasoconstriction

Use: Acute migraine, cluster headache attacks

AE: Coronary vasospasm