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Flashcards in Parkinson's Deck (16):
1

4 Components of PD Def

Neurodegenerative, slowly progressing, synuclein accumulation, characterized by hypokinetic movement disorder

2

Diagnostic Criteria (4)

Bradykinesia, w/ at least one of: Tremor at rest, rigidity, loss of postural reflexes

3

Nonmotor Features

Things like autonomic dysfunction/sleep disturbance/smell loss/constipation from multisystem NT loss can appear decades before clinical onset

4

Freezing

Most disabling symptom of PD, motor blocks leading to only very small slow movements

5

2 Main Kinds of PD

Tremor Dominant - good prognosis, responds well to treatment for a long time
Non-Tremor Dominant - more rapid, early gait impairment and other motor systems

6

Parkinsonism

Not quite Not quite PD, instead like it. Can be secondary to other things like stroking out BG or drug use affecting DA. Normally tauopathy, not synuclein

7

DAT Imaging

Shows reduced presyanptic stuff

8

Vulnerability of Striato-nigral Neurons

DA predisposes to oxidative stress, so get mt depletion and synuclein aggregation

9

Lewy Bodies

Eosinophilic cytoplasmic inclusions that show where PD has spread to in brain

10

Braak Staging (3)

1/2 is autonomic/olfactory, 3/4 is sleep and motor, 5/6 is all throughout brain and get emotional/cognitive disturbances. Lewy bodies spread to these places

11

PD Physiology

Increased firing from STN/Gi (greater indirect) bc less DA firing from STN

12

4 Treatment Stages

Honeymoon period
Motor complication period
Resistant symptoms
Cognitive decline period

13

Carbidopa

Carboxylase inhibitor, prevents conversion of L-Dopa to DA to avoid huge influx w/ side effects

14

2 Dopa Sparing Strategies for Early PD

MAO Inhibitors Type B
DA Agonists (ropinerole, delay L-Dopa dyskinesia)

15

2 Motor Complications from L-Dopa

Dyskinesia
Wearing Off - symptoms reoccur b/w doses

16

Deep Brain Stimulation

Of subthalamic nucleus, used in honeymoon period or when motor complications occur w/ normal treatment (dyskinesia, wearing off)