Part 1 Flashcards
(20 cards)
PHYSIOLOGIC EFFECTS OF DRUGS ARE AFFECTED BY THE FOLLOWING:
Altered Blood Pressure
Altered Heart Rate
Altered Urinary Output
Altered Function of CNS and PNS
Changes in all other body system
Macromolecular component of the body tissue that receives the maximum effect of a drug.
DRUG RECEPTOR
Determines drug concentration to accomplish intended attraction between drug and receptor
AFFINITY
Concentration of drug to accomplish its intended effect.
EFFICACY OF DRUGS
Bind to receptor and produces therapeutic effect.
A drug or natural substance with an affinity for specific receptor sites that produces a physiologic response, usually predictable
AGONIST
Partial binding at a receptor and produce partial therapeutic effect.
PARTIAL AGONIST
Joins receptor and prevents agonist from performing its intended effects.
Drugs with _____ activity will block receptors for which they have affinity.
ANTAGONIST
Dosages of which intended effect is obtained and the amount that produces unwanted effect.
A measure of the relative safety of a drug.
THERAPEUTIC INDEX
DRUG COMBINATION OR COMBINING TWO DRUGS MAY CAUSE:
To become inactive
To form a toxic compound
To increase the effect of each drug given alone
(additive reaction)
To equal an effect greater than sum of their separated dose (Synergistic Reaction)
To either neutralize or decrease intended effect
Common, unintended, and non-toxic reactions
SIDE EFFECT
More severe and life threatening reactions.
ADVERSE
Unwanted effect that is extension of therapeutic effect.
TOXIC REACTIONS
unexpected or exacerbated effect
DRUG IDIOSYNCRASY
sign of drug dependence.
DRUG TOLERANCE
rapid development of tolerance to a drug
TACHYPHYLAXIS
results from an immune-mediated response by the body against the drug
ALLERGIC REACTION
It is the area of pharmacology that focuses on the method for achieving effective drug administration. Drugs are placed into vehicles by the manufacturing process
BIOPHARMACEUTICS
It is a substance into which a drug is compounded for initial delivery into the body.
DRUG VEHICLE
Solid, liquid, gas, or any combination of these is the combination of both the drug and the vehicle used to deliver the drug.
_______used for oral administration include tablets, capsules, and troches
DOSAGE FORM
The organ on or in which the desired effect occurs.
TARGET ORGAN
