PASSMEDICINE Flashcards
1
Q
What kind of mutation leads to downs?
A
Non-dislocation- where the chromosomes do not separate during meiosis during cell division
2
Q
Cycle of mitosis
A
Prometaphase: Nuclear membrane breaks down allowing the microtubules to attach to the chromosomes
Metaphase: Chromosomes aligned at middle of cell
Anaphase: The paired chromosomes separate at the kinetochores and move to opposite sides of the cell
Telophase: Chromatids arrive at opposite poles of cell
3
Q
What is p53
A
Tumour suppressor gene- encodes proteins which regulate the cell cycle
4
Q
Pattern for chronic respiratory failure?
A
- High PaCo2
- Low 02
- High HCO3-
