Path 9 MEN syndromes Flashcards Preview

Test 9 > Path 9 MEN syndromes > Flashcards

Flashcards in Path 9 MEN syndromes Deck (17)
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1
Q

Delta cells

A

Somatostatin - suppress insulin and glucagon release

2
Q

D1 cells

A

VIP - induce glycogenolysis/hyperglycemia and GI fluid secretion

3
Q

Pancreatic enterochromaffin cells

A

Serotonin

4
Q

Insulinoma

A

Most common pancreatic endocrine neoplasm

-90% benign

5
Q

Insulinoma findings

A

Whipple’s triad: Hypoglycemia, CNS symptoms, reversal by glucose administration

6
Q

Insulinoma histo

A

Enlarged islet

  • No anaplasia
  • Amyloid deposition
7
Q

2 tumors with amyloid deposition

A

Insulinoma

Medullary thyroid carcinoma (calcitonin)

8
Q

Gastrinoma

A

Zollinger-Ellison Syndrome

  • Gastrinoma triangle (mostly duodenum)
  • Multiple peptic ulcers
  • Usually metastatic to liver
9
Q

Glucagonoma

A

a-Cell tumor

  • Mild diabetes (hyperglycemia)
  • Necrolytic migratory erythema
  • Anemia
10
Q

VIPoma

A

WDHA (pancreatic cholera) syndrome

-Watery Diarrhea, Hypokalemia, Achlorhydria

11
Q

MEN type 1

A

Wermer syndrome

-3 Ps (Parathyroid, Pituitary, Pancreas)

12
Q

MEN type 1 more specific

A
  • Parathyroid hyperplasia/adenomas
  • Pituitary Prolactin or GH adenomas
  • Pancreas Gastrinomas and Insulinomas
13
Q

MEN1 gene

A

Tumor suppressor gene

-Product is menin, cell cycle regulator

14
Q

MEN type 2a

A

Sipple syndrome

  • Familial Medullary Thyroid Cancer (slow)
  • Pheochromocytomas
  • Parathyroid hyperplasia
15
Q

MEN2a/b gene

A

RET proto-oncogene mutation

16
Q

RET gain of function v loss of function

A

MEN2 v Hirschsprung

17
Q

MEN type 2b

A
  • Medullary Thyroid Carcinoma (aggressive)
  • Neuromas
  • Marfanoid habitus