Patho- NMJ disorders Flashcards Preview

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Flashcards in Patho- NMJ disorders Deck (13)
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1
Q

Name two NMJ disorders

A

Myasthenia Gravis

Lambert-Eaton myasthenic-myopathic syndrome (LEMS)

2
Q

What is the pathology of myasthenia gravis?

A

Autoimmune attack of AChR

3
Q

What are some symptoms of myasthenia gravis?

A

Muscle weakness and fatigability in proximal muscles, bulbar muscles and ocular muscles
Resp difficulties
No muscle pain
Reflexes disappear on prolonged use

4
Q

Who tends to get myasthenia gravis?

A

30s

Women>men

5
Q

What kind of resp difficulties can myasthenia gravis sufferers develop?

A

Resp impairment
Nasal regurgitation
Dysphagia

6
Q

What type of antibody causes myasthenia gravis?

A

IgG

7
Q

What diseases can myasthenia gravis be associated with?

A

Thyroid
RA
Pernicious anaemia
SLE

8
Q

How can myasthenia gravis be diagnosed?

A

Clinical- Fluctuating, fatigable weakness
Serum Anti-AChR antibodies
Progressive decreased AP on EMG

9
Q

How do you treat myasthenia gravis?

A

Support resp
Oral anticholinesterases- Pyridostigmine
Immunosuppressant drugs- Steroids
Thymectomy

10
Q

What is the patho of Lambert-Eaton myasthenic-myopathic syndrome (LEMS)

A

Paraneoplastic manifestation of small-cell bronchial carcinoma
Defective acetylcholine release at the NMJ

11
Q

What are some symptoms of LEMS?

A

Proximal limb muscle weakness- Resolves after a few minutes of muscle contraction
Absent reflexes

12
Q

How do you diagnose LEMS?

A

EMG

Antibodies to P/Q-type voltage-gated calcium channels

13
Q

How do you treat LEMS?

A

Treat underlying cause

Diaminopyridine (DAP)