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Flashcards in Pathology Deck (113):
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Mucoviscidosis

Cystic Fibrosis

1

Calcium soap formation

Saponification

2

Not promptly destroyed necrotic cells reabsorbed and attract calcium salts and other minerals and become calcified

Dystrophic calcification

3

Fragments of DNA in apoptotic cells

DNA ladders

4

Large homogenous eosinophilic inclusions produced by distended ER secondary to excess production of normally secreted proteins

Russell bodies

5

Immature B and T cells

Lymphoblasts

6

Macrophage in burkitt lymphoma

Burkitt cells

7

Treatment for ALL

Asparaginase

8

CD 33, CD 34 positive

AML

9

Aleukemic leukemia

AML

10

Auer rods

APML > AML

11

Leukemia with spontaneous mucosal and cutaneous bleeding

AML

12

Leukemia with CNS involvment

ALL

13

T(15;17)

APML

14

Chloroma

Blast crisis of CML

15

Dry tap on BMA

Hairy cell leukemia

16

Ann Arbor Staging

Hodgkins lymphoma

17

T(14;18)

Follicular lymphoma

18

Cloverleaf cells

Adult t cell lymphoma

19

Cd4 t cells in band like aggregates

Sezary lutner cells

20

Russell bodies

Multiple myeloma

21

Pseudo pelger huet cells

MDS

22

Panmyelosis

Polycythemia vera

23

In polycythemia, ESR will

Decrease

24

Skin blisters are ____ type of inflammation

Serous inflammation

26

Type of collagen deficient in achondrogenesis type II

Type II collagen

27

Phase of wound healing where there is already collagen deposition

Maturation phase

34

TGF-B is impt in synthesis of

Collagen

35

Heart failure cells are found in

Chronic pulmonary congestion

36

Nutmeg liver

Chronic Passive congestion (CPC)

37

Blood, CSF and brain tissue in volume equilibrium

Monro-kellie doctrine

38

Pathologic counterpart of hemostasis

Thrombosis

39

Arteriolar vasoconstriction is transiently augmented by secretion of

Endothelin

40

Antibodies in APAS

Anti-cardiolipin
Lupus anticoagulant

41

Tigered effect is seen in

Fatty change (steatosis) in Heart

42

Distinguishes antemortem fibrosis from postmortem fibrosis

Lines of Zahn (lamination)

43

Difference of Postmortem Lividity from Postmortem Thrombosis

PL is in direct contact with surfaces
PT is not attached to underlying wall

44

Thrombi on heart valves called

Vegetations

45

Endocarditis in SLE patients

Libman sacks endocarditis

46

Bacterium in MARANTIC ENDOCARDITIS

Streptococcus bovis

47

Cardiac tamponade will lead to what type of shock

Cardiogenic shock

48

Pulmonary embolism will lead to what type of shock

Cardiogenic shock

49

Heart failure cells are found in

Chronic pulmonary congestion

50

Nutmeg liver

Chronic Passive congestion (CPC)

51

Blood, CSF and brain tissue in volume equilibrium

Monro-kellie doctrine

52

Pathologic counterpart of hemostasis

Thrombosis

53

Arteriolar vasoconstriction is transiently augmented by secretion of

Endothelin

54

Antibody seen in limited form of scleroderma

Anti-centromere

55

Type of graft with best survival rate

Autograft

56

Acute cellular rejection causes endothelitis
Acute humoral rejection causes what vascular injury

Necrotizing vasculitis

57

Treatment of Bruton's XLA

Pooled gamma globulin

58

C3 deficiency - recurrent infection due to what bacteria

S.aureus

59

Sago spleen or lardaceous spleen is seen in

Amyloidosis

60

Proto-oncogene: abl

CML

61

Proto-oncogene: c-myc

Burkitt lymphoma

62

Proto-oncogene: bcl-2

Follicular lymphoma

63

Proto-oncogene: Erb-b2

Breast CA
Ovarian CA
Gastric CA

64

Proto-oncogene: K-ras

Colon CA

65

Proto-oncogene: L-myc

Lung CA

66

N-myc

Neuroblastoma

67

Proto-oncogene: ret

MEN types II and III

68

Proto-oncogene: c-kit

GIST

69

Tumor suppressor gene: p16

Melanoma

70

Tumor suppressor gene: APC

Colorectal CA

71

Tumor suppressor gene: WT1

Wilms tumor

72

Tumor suppressor gene: DPC

Pancreatic CA

73

Tumor suppressor gene: DCC

Colon CA

74

Tumor suppressor gene: Rb

Retinoblastoma
Osteosarcoma

75

Mendelian disorder
Affected male parent with unaffected wife transfer gene to all his daughters but none of his sons

X-linked Dominant

76

Affected mother transfer genes to all offspring

Mitochondrial inheritance

77

Mutant gene present but phenotypicly normal

Incomplete penetrance

78

Mendelian d/o
Many generations affected
Age onset is delayed

Autosomal dominant

79

Mendelian d/o
Clinically presents at childhood
Seen in 1 generation only

Autosomal recessive

80

Affected male does not transmit gene to sons
All daughters are carriers

X-linked recessive

81

Ectopia lentis is seen in

Marfan syndrome

82

Lysosomal accumulation of sphingomyelin

Niemann pick disease type a and b

83

Zebra bodies found in

Niemann pick disease

84

Distended phagocytic cells with crumpled tissue paper appearance

Gaucher cells

85

Intracytoplasmic glycogen accumulation in muscle only

McArdle's (type V)

86

Prototype trinucleotide repeat dse

Fragile x synd

87

Happy puppet syndrome is C/M in _____ syndrome

Angelman

88

Type of hypersensitivity leading to complement mediated cell lysis

Cytotoxic hps
Type II

89

Autoantibody in SLE

ANA
Anti-dsDNA

90

Autoantibody in drug induced lupus

Anti-histone

91

Autoantibody in mixed connective tissue dse

Anti-RNP

92

Autoantibody in CREST syndrome

Anti-centromere

93

Autoantibody in diffuse scleroderma

Anti-scl70

94

Autoantibody in sjogren syndrome

Anti-SS-A

95

Autoantibody in primary biliary cirrhosis

Anti-mitochondrial

96

Fragmented RBCs

Schistocytes

97

RBC with spikes

Burr cells/Echinocytes

98

Macro-ovalocyte RBCs are seen in

Megaloblastic anemia

99

Antibody causing Immune Thrombocytopenic Purpura

Anti-platelet antibody

100

Congestion of splenic sinusoids
Megakaryocytic hyperplasia in bone marrow
Megathrombocytes in peripheral blood

Immune thrombocytopenic purpura

101

Fever
Thrombocytopenia
Microangiopathic hemolytic anemia
Neurologic deficits
Renal failure

Thrombotic thrombocytopenic purpura

102

Treatment for Von Willebrand Disease

Desmopressin
Concentrates containing Factor VIII and vWF

103

Widespread microthrombi in placenta

Toxemia of pregnancy

104

Acute herpetic gingivostomatitis is caused by

HSV-1

105

Nests of round to oval chief cells surrounded by delicate vascular septae

Zellballen
(Paraganglioma)

106

Dendritic cells in skin are called

Langerhans

107

First histologic change in progression of dysplastic nevus to melanoma

Lentiginous hyperplasia

108

Vertical growth phase of melanoma is heralded by appearance of a

Nodule

109

Dermatitis herpetiformis is associated with what intestinal disease

Celiac disease

110

Earliest histologic lesion in melanocytic nevus

Junctional nevi

111

Most common location of Paragangliomas

Carotid bodies

112

Components of OEIS complex

Omphalocoele
Extrophy (bladder)
Imperforate anus
Spina bifida

113

Rescue therapy for Doxorubicin

Dexrazoxane

114

Rescue therapy for Cisplatin

Amifostine

115

Dominant symptom and sometimes the only clinical manifestation of urothelial cancers

Painless hematuria

116

Fibromatosis of Buck's fascia causing penile curvature

Peyronie disease

117

Bell clapper deformity is seen in

Testicular torsion

118

Blood vessel invaded in Syphilitic aneurysm

Vasa vasorum of thoracic aorta

119

Pre existing histologic lesion of Aortic dissection

Cystic medial degeneration