Pathology of Idiopathic Inflammatory Bowel Disease Flashcards Preview

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Flashcards in Pathology of Idiopathic Inflammatory Bowel Disease Deck (18):
1

Define Chron's

Chronic inflammatory and ulcerating condition of the GI tract that can affect anywhere from the mouth to the anus

2

Where is Crohn's disease most common

In the terminal ileum and colon

3

Who is most commonly affected by Crohn's disease

Young patients 10-40
Males most commonly

4

What are 6 common presentations of Crohn's disease

Abdominal pain
Small bowel obstruction
Diarrhoea
Bleeding PR
Anaemia
Weight loss

5

Describe the clinical course of Crohn's Disease

Chronic
Exacerbations and remissions
Unpredictable response to therapy

6

What are significant features of crohn's disease in histology

Granuloma formation
Increased inflammatory cells in the lamina propria

7

What are the appearance of deep fissures in Crohns disease (histology)

Knife like in appearance

8

What are complications of malabsorption in Crohn's disease

Malabsorption
Latrogenic due to repeated resections
Hypoproteinemia, Vtiamin deficiency, anaemia
Gallstones

9

What are other complications of crohns disease

Fistulas
Anal Disease
Intractable disease
Bowel obstruction
Perforation
Malignancy
Amyloidosis

10

What causes Crohn's disease

Genetic susceptibility and environmental agents

11

Define Ulcerative colitis

Chronic inflammation idsorder confined to colon and rectum with mucosal and submucosal inflammation

12

Who is most likely to have ulcerative colitis

Young patients mostly male
but can present in children and elderly

13

What part of the GI tract is affected by Ulcerative colitis

Colon and rectum (usually the rectum)

14

What are the common clinical presentations of Ulcerative colitis

Diarrhoea, mucus and blood PR

15

What are 4 aspects of the clinical course of ulcerative colitis

Chronic course with exacerbation and remission
Continous low grade activity
A single attack
Acute fulminatn colitis

16

What are some common observations (histology)

Massive influx of inflammatory cells
Basal lymphoplasmacytic infiltrate with irregular shaped branching crypts
Acute cryptitis
Crypt abscesses
Sever ulceration
Pseudopolyps
No granulomas
Rarely fistulae

17

Where is the inflammation confined to in Ulcerative colitis

The mucosa and submucosa (superficial)

18

What are some common complications of Ulcerative colitis

Intractable disease - continuous diarrhoea and total colectomy
Toxic megacolon
Colorectal carcinoma
Blood loss
Electrolyte disturbnace
Anal fissures
Extra GI manifestations (eyes, liver, joints, skin)

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