Flashcards in Pathology of the Colorectal Carcinoma Deck (43)
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1
What is a polyp?
A protrusion above an epithelial surface
2
Is a polyp benign or malignant?
Can be either
3
What are some examples of benign epithelial polyps
Neoplastic (adenoma inflammatory IBD)
Hamartomatous (juvenile polyp )
4
What is a type of malignant epithelial polyp?
Polypoid (adenocarcinomas or carcinoid polyps
5
What are the 3 different types of macroscopic
Pedunculated
Sessile
Flat
6
Describe pedunculated polyps
Hangs on a long stalk form the mucosa and is mushroom like- easy to remove
7
Describe sessile polyps
Carpet like - difficult to cut out as over a longer area
8
What is dysplastic epithelial lining
Epithelium that has failed to mature
9
Describe adenomas of the colon
Benign tumours which are not invasive and have the potential to develop into cancers
10
How can we reduce the risk of cancer?
Screen the colon and remove all adenomas
11
What are the 3 different microscopic architecture variability
Tubullovillous (tree like)
Tubular (large circles)
Villous (Finger like projections)
12
What are all adenomas?
Dysplastic
13
What can happen if adenomas are left?
They can lead to cancer
14
Describe the adeoma-carcinoma sequence
Normal mucosa,
adenoma (dysplastic)
Adenocarcinoma (invasive)
15
Why must all adenomas be removed?
How is this done?
Because they are all premalignant
Either done endoscopically or surgically
16
Do all colorectal adenomas have the same molecular genetic origins?
No
17
What causes the variation in colorectal adenomas
separate pathways for injerited tumours
Sparate pathways for serrated adenomas
18
What is the primary treatment in most cases of adenocarinoma of the large bowel
Surgery
19
How is the tumour staged?
Endoscopic biopsy sent to pathology
20
Why are gland cells formed?
They are derived from stem cells which give rise to large colonic crypts which still contain traces of normality
21
How does cancer spread to the serosal fat?
Invades through the muscle
22
How do we stage colorectal carcinoma
Using Duke's staging
23
What are the 3 stages of Duke's staging?
Dukes A: Confined by muscularis propria
Dukes B: Through muscularis propria
Dukes C: Metastatic to lymph nodes
24
Where are most colorectal carcinomas found?
75% Left side (rectum,sigmoid descending)
25% Right side (Caecum, ascending)
25
What are the common presentations of left sided colorectal carcinomas?
Blood PR, Altered bowel habit and obstruction
26
What are the common presentations of right sided colorectal carcinomas
Anaemia, weight loss
No PR bleeding
27
Why do some tumours appear to be glistening?
Due to the mucous which is produced from the tumour
28
What might be affected by local invasion
Mesorectum, peritoneum, other organs such as the bladder, ovary or prostate, uterus or vagina
29
What might be affected by lymphatic spread
Mesenteric nodes
30
