Flashcards in Pelvic Floor Disorders Deck (38)
What are the 3 general categories of pelvic floor disorders?
Pelvic Organ Prolapse
In what age group is the incidence of UI/POP the highest?
What are some urethral causes of urinary incontinence?
Urethral sphincter incompetence
Retention with overflow
What are some extraurethral causes of urinary incontinence?
What is the incidence of USI?
1/3 in women over 55yo
What are the RFs for UI?
Smoking (chronic cause, increased risk of overactive bladder)
What is overactive bladder syndrome?
Urgency, with or without urge urinary incontinence, usually with frequency and nocturia in the absence of pathologic or metabolic conditions that might explain these symptoms
What is the difference between OAB wet and dry?
Wet has (urge) incontinence, in dry it is absent
What is mixed UI?
Involuntary leakage associated with urgency and also with exertion, sneezing, or coughing (SUI)
What evaluation should be carried out in UI Ix?
Post void residual
When can pelvic floor exercises be used?
Not in UUI
(Min 3 months)
What pharmacological therapy can be used for OAB syndrome?
What effects do antimuscarinics have on urination?
Reduce intra-vesical pressure
Raise volume threshold for micturition
Reduce uninhibited contractions
What are some S/E of antimuscarinics?
What should be used in OAB if antimuscarinics have been deemed ineffective or are contraindicated?
Mirabegron- β3 Agonists
What is the MOA of β3 Agonists?
Relax bladder smooth muscle through activation of the β3 adrenoceptor
Selective agonist for the human β3 adrenoceptor with low intrinsic activity for β1 and β2
Increase voiding interval and inhibit spontaneous bladder contractions during filling suggesting a potential clinical application for these agents
What specific drug choices should be offered first to women with OAB or MUI?
Oxybutynin (immediate release) or
Tolterodine (immediate release) or
Propiverine (immediate release)
What are 2nd line antimuscarinic treatments for OAB?
Trospium (immediate release) or
Oxybutynin (extended release) or
An alternative immediate release drug
What is uroflowmetry?
Measurement of volume of urine (ml) expelled from the bladder each second
When is uroflowmetry indicated?
History of urine retention
Post-operative follow up
When are multichannel urodynamics indicated?
Fail respond to treatment
What does flow rate enable you to measure?
Voided volume (minimum 200mls void required)
What is cystometry?
A method by which the pressure/volume relationship of the bladder is measured during filling, provocation and during voiding
What is an abnormal Post Void Residual (PVR)?
What are the causes of overflow incontinence?
Obstruction of urethra
Poor contractile bladder muscle
What must be found out in OUI?
What must be stopped in OUI?
What is the conservative treatment of SUI?
Drugs: duloxetine (combined noradrenaline and serotonin reuptake inhibitor- increases intraurethral closure pressure)
Others- pads, vaginal pessaries
What is the surgical treatment of SUI?
Low tension vaginal tape