Pentose Phosphate Pathway Flashcards Preview

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Flashcards in Pentose Phosphate Pathway Deck (21):
0

_____ converts ribulose-5-phosphate to ribose 5-phosphate , _____ converts ribulose-5-phosphate to xylulose-5-phosphate

Isomerase
Epimerase

1

Transketolase converts xylulose-5-phosphate and ribose-5-phosphate to ____

Glyceraldehyde 3-phosphate
Sedoheptulose 7-phosphate

2

Transaldolase converts Glyceraldehyde 3-phosphate and
Sedoheptulose 7-phosphate to

Erythrose 4-phosphate
Fructose 6-phosphate

3

Transketolase requires _____ as a cofactor

Thiamine pyrophosphate

4

Transketolase transfers a ____ carbon keto fragment , transaldolase transfers a ____ carbon keto fragment

2 3

5

NADPH, rather than NADH, is used primarily for reductive reaction in the cell because ratio of NADPH/NADP+ is much _____ than ratio of NADH/NAD+

Higher

6

NADPH cannot be directly oxidized by ____

ETC

7

The reduction potential of NADPH can contribute to energy needed for ____ process and a constant source of reducing power for _____

Bio synthetic
Detoxification reaction

8

Name 3 type reactions in the Conversion of Glucose 6 phosphate to ribulose 5 phosphate

Oxidation
Hydrolysis
Decarboxylation

9

If the cell needs nucleotide but not NADPH, the _____ phase is inhibited and ribose 6-p will be generated from glycolytic intermediate using the _____ phase

Oxidative
Nonoxidative

10

If the cell needs NADPH but not nucleotide, the oxidative phase is _____, and ribose 5-P will be converted to ______ through nonoxidative phase

Activated
Glucose 6-P

11

All cells require_____for reductive detoxification , and most cells require _____ for nucleotide synthesis

NADPH
Ribose-5-P

12

The oxidative stage of PPP generates ___ NADPH for each G-6-P oxidized

2

13

_____ is used for the reduction of oxidized glutathione.

NADPH

14

Glutathione is necessary for the removal of _____ and ______ generated by ROS

H2O2
Lipid peroxide

15

The glutathione defense system is compromised by _________, infection, drugs, purine glycosides of fava beans

Glucose 6-P dehydrogenase deficiency

16

_______ are formed on the cell membrane of RBC by damage to hemoglobin due to oxidative damage, it is an aggregates of _____

Heinz bodies
Cross-linked hb

17

The action of ROS on the cell membrane as well as mechanical stress from the lack of deformability result in_____

Hemolysis

18

____ catalyzes first step of PPP

Glucose 6 phosphate dehydrogenase

19

In oxidative phase of PPP, glucose-6-phosphate is oxidized to _____

Ribulose-5-phosphate
CO2
NADPH

20

For every 3 glucose 6-phosphate that enters PPP, ___ fructose 6-P and ___ glyceraldehyde 3-P

2, 1