Flashcards in pH Deck (20):
What is Type 1 Diabetes
Autoimmune disease. Body attacks the beta cells in the pancreas and kills them so no insulin can be produced.
What is Type 2 Diabetes
Body has difficulty producing insulin based on pathways. Think Randal's class.
What does an increase in glucose do?
Release fatty acids
What do fatty acids produce? What's its pKa?
Ketones and their pH is lower than physiological pH of 7.4
Do enzymes require a specific pH?
Name 3 enzyme examples for pH
1. Pepsin in the stomach (pH of 2ish)
2. Trypsin in the duodenum (pH of 6ish)
3. Alkaline Phosphatase in the mitochondria (pH of 8-9ish)
What are 3 ways pH can change an enzyme?
1. Loss of activity
2. Loss of solubility
3. Loss of shape
Does the blood in the lungs or tissues have a higher pH
Is Hgb more saturated at lower or higher pH's?
Golgi (cis) pH
Golgi (medial) pH
Golgi (trans) pH
What is the buffer system in blood? Is it good?
Bicarbonate; No. It's pKa is lower than physiological pH