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pH - Foundations 08-10-17 > pH > Flashcards

Flashcards in pH Deck (20):
1

What is Type 1 Diabetes

Autoimmune disease. Body attacks the beta cells in the pancreas and kills them so no insulin can be produced.

2

What is Type 2 Diabetes

Body has difficulty producing insulin based on pathways. Think Randal's class.

3

What does an increase in glucose do?

Release fatty acids

4

What do fatty acids produce? What's its pKa?

Ketones and their pH is lower than physiological pH of 7.4

5

Do enzymes require a specific pH?

Yes

6

Name 3 enzyme examples for pH

1. Pepsin in the stomach (pH of 2ish)
2. Trypsin in the duodenum (pH of 6ish)
3. Alkaline Phosphatase in the mitochondria (pH of 8-9ish)

7

What are 3 ways pH can change an enzyme?

1. Loss of activity
2. Loss of solubility
3. Loss of shape

8

Does the blood in the lungs or tissues have a higher pH

Lungs

9

Is Hgb more saturated at lower or higher pH's?

Higher

10

Nucleus pH

7.2

11

ER pH

7.0

12

Golgi (cis) pH

6.7

13

Golgi (medial) pH

6.3

14

Golgi (trans) pH

6.0

15

Mitochondria pH

8.0

16

Cytosol pH

7.2

17

ECM pH

7.4

18

Lysosome pH

4.5

19

What is the buffer system in blood? Is it good?

Bicarbonate; No. It's pKa is lower than physiological pH

20

What is a better buffer?

Phosphate. Its pKa is closer, but is much lower in quantity.