Pharm

Question 1

Which muscarininc receptor uses a dec in adenyl cyclases as its second messenger?

Answer 1

M2

Question 2

what drug is used to differentiate a cholinergic crisis from myasthenia gravis?

Answer 2

Edrophonium

Question 3

what drug causes a gradual loss of choline from the presynaptic nerve terminal by blocking its reuptake?

Answer 3

hemicholium

Question 4

what is the only site in the body that uses M1 receptors?

Answer 4

stomach

Question 5

what drug is an M1-specific antispasmodic?

Answer 5

pirenzepine

Question 6

what is the most potent NMJ blocker and also has no CV side effects?

Answer 6

Doxacurium

Question 7

what antimuscarinic is used as an inhalant for asthma?

Answer 7

Ipratropium

Question 8

what is the antidote ofr organophosphate ingestion?

Answer 8

atropine and 2-PAM (pralidoxime)

Question 9

what is the drug of choice for atropine or TCA overdose?

Answer 9

physostigmine

Question 10

What is the rate-limiting step for NE synthesis?

Answer 10

tyrosine hydroxylase

Question 11

what 2 enzymes are blocked by disulfiram?

Answer 11

aldehyde dehydrogenase and dopamine B-hydroxylase

Question 12

what is the monoamine oxidase B (MAOB) inhibitor?

Answer 12

selegiline

Question 13

what 2 drugs inhibit the relase of neurotransmitters from storage granules?

Answer 13

1. Guanethidine2. Bretylium

Question 14

what drug blocks intragranular uptake of NE?

Answer 14

reserpine

Question 15

what 2 drugs, when mixed, can lead to malignant hyperthermia?

Answer 15

1. Succinylcholine

2. Halothane (tx is with dantrolene)

Question 16

in what phase of nocompetitive depolarization does no further depolarization occur, producing a desensitized block?

Answer 16

phase 2

Question 17

what adrenergic receptors use inositol triphosphate (IP3) and diacylglycerol (DAG) for their second messenger system?

Answer 17

alpha1-receptors

Question 18

what alpha1-agonist is used to tx paroxysmal atrial tachy with hypotension?

Answer 18

metaraminol (alpha1, beta1)

Question 19

what alpha1-agonist, not inactivated by catechol-o-methyl transferase (COMT), is used as a decongestant and also for tx of paroxysmal atrial tachy?

Answer 19

phenylephrine

Question 20

what b2-agonist is used in the prophylactic tx of asthma?

Answer 20

Salmeterol

Question 21

What 2 B2-agnoists cause myometrial relaxation?

Answer 21

1. Ritodrine

2. Terbutaline

Question 22

A hypertensive crisis can be caused by the addition of an MAO inhibitor and what?

Answer 22

tyramine

Question 23

what group of drugs is known as the “antihypertensive” group?

Answer 23

alpha1-antagonists

Question 24

Half lives: how long does it take for a drug to reach a final steady state of 87.5%?

Answer 24

1 half-life: 50%
2 half-lives: 75%
3 half-lives: 87.5%
4 half-lives: 93.75%