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Flashcards in pharm Deck (12):
1

Aliskiren. describe effect. Good for combination therapy?

renin inhibitor. dose-dependent effect. monotherapy better than combining with ACEI or ARB

2

-pril

ace inhibitor

3

-sartan

AT2 blocker

4

Aldosterone antagonists

spironolactone

5

how does captopril work

competitive inhibition. fits into ace active site

6

What treatments produce greatest albumin and protein reduction in urine in pts with DM?

ACE> CCBs, beta blockers, ARBs

7

what are side effects of ACEI's

Angioedema (^ bradykinin -> vasodilation and ^ vascular permeability). Cough

8

what effect does losartan have in DM pts?

decreased albuminuria and TGF-beta1. also, decreased BP and better endpoint

9

Do RAAS inhibitors cause cancer?

No. In fact, they may actually reduce basal and squamous cell carcinomas

10

What has been proven to significantly decrease mortality in pts with LVSD? Side effects?

spironolactone. gynecomastia. Eplerenone doesnt cause gynecomastia

11

Compare use of torsemide and furosemide. Side effects?

oral furosemide is erratic. Torsemide is better. Either is fine IV. Furosemide causes wasting of water soluble vitamins like thiamine causing beriberi

12

when should you give vanc in a dialysis pt? Why?

right after dialysis.You get re equilibration from the slowly equilibrating compartment