Flashcards in pharm Deck (12):
Aliskiren. describe effect. Good for combination therapy?
renin inhibitor. dose-dependent effect. monotherapy better than combining with ACEI or ARB
how does captopril work
competitive inhibition. fits into ace active site
What treatments produce greatest albumin and protein reduction in urine in pts with DM?
ACE> CCBs, beta blockers, ARBs
what are side effects of ACEI's
Angioedema (^ bradykinin -> vasodilation and ^ vascular permeability). Cough
what effect does losartan have in DM pts?
decreased albuminuria and TGF-beta1. also, decreased BP and better endpoint
Do RAAS inhibitors cause cancer?
No. In fact, they may actually reduce basal and squamous cell carcinomas
What has been proven to significantly decrease mortality in pts with LVSD? Side effects?
spironolactone. gynecomastia. Eplerenone doesnt cause gynecomastia
Compare use of torsemide and furosemide. Side effects?
oral furosemide is erratic. Torsemide is better. Either is fine IV. Furosemide causes wasting of water soluble vitamins like thiamine causing beriberi