Pharm First Aid Toxicities and Side-Effects Flashcards Preview

STEP I 2014 > Pharm First Aid Toxicities and Side-Effects > Flashcards

Flashcards in Pharm First Aid Toxicities and Side-Effects Deck (72):
1

treatment for Acetominiophen

N-acteylcystine (releplenises glutahione)

2

AChE inhbitors, organophosphates OD

atropine followed by pralidoxime

3

Amphetamine (basic) OD

NH4Cl (acidify urine)

4

antimuscarinics, anticholingeric agents OD

physostigme salicylate, control HTN

5

Benzodiazepine OD

flumazenil

6

beta blocker OD

glucagon (glucagon stimulate adenylyl cyclase and increases intracellular cAMP in many different tissues. In the heart this result in increase of heart rate and force of contraction:)

7

Carbon Monoxide OD

100% O2 and Hyperbaric O2

8

copper, arsenic gold OD

penicillamine

9

cyanide OD

nitrite+thiosulfate, hydroxocarbalamin

10

digitalis OD

anti-dig Fab fragments

11

heparin OD

protamine sulfate

12

iron OD

deferoxamine, deferasirox

13

Lead OD

EDTA, dimercaperol, succinmer, penicillamine

14

Mercury, arsenic gold OD

dimercaperol (BAL), succimer

15

methanol, ethlyene glycol (antifreeze) OD

fomepizole >ethanol, dialysis

16

methemoglobin OD

methylene blue, vit C

17

opiods OD

naloxone

18

salicylates OD

NaHCO3 (alkalinize urine), dialysis

19

TCAs OD

NaHCO3 (plasma alkalinization)

20

tPA, streptokinase, urokinase OD

aminocaproic acid

21

Warfarin OD

vit K, plasmis (if active bleeding)

22

CV: 3 drugs that cause vasospasm

cocaine, sumatriptan, ergot alkaloids (bromocriptine)

23

CV: 4 D that cause cutaneous flushing

VANC, vancomycin, adenosine, niacin, Ca2+ channel blockers

24

CV: 2 drugs that cause dilated cardiomyopathy

doxorubicin, danorubicin

25

CV: 7 Ds that cause torsades de pointes

class III (i.e. sotalol), class IA (quinidine) antiarrhythmics, macrolide antibiotics, antipsychotics, TCAs

26

Endo/Repro: 1 D that causes andrenocortical insufficiency

HPA suppression secondary to glucoccorticoid withdrawl

27

Endo/Repro: 2 D that cause hot flashes

tamoxifen, clomiphene

28

Endo/Repro: 6 D that cause hyperglycemina

taking pills necessitates having blood checked
tacrolimus, protease inhbiitors, niacin, HCTZ, beta blockers, corticosteriods

29

Endo/Repro: 3 Ds that cause hypothyroidism

lithium, amiodarone, sulfonamides

30

GI: 1 D that causes acute cholestatic hepattitis

erythromycin

31

GI 5 D that cause diarrehea

metformin, erythromycin, colchicine, orlistat, acarbose (might excrete colon on accident)

32

GI: 4 drugs that cause focal to massive hepatic necrosis

halothane, amanita phalloides (death cap mushroom), valproic acid, aceteaminphen- (Liver HAVAc)

33

GI 1 drug that causes Hepatitis

INH

34

GI: 6 drugs that case pancreatitis

Drugs causing a violent abdominal ditress
didanosine, corticosteroids, alcohol, valproic acid, azathioprine, diuretics (furosemides, HCTZ)

35

GI: 3 Ds and 1 bacteria that cause pseudomembraneous colitis

clindamycin, ampicillin, cephalsporins- antibiotics predispose to superinfection by resistance c. difficile

36

Heme: 6 Ds that cause agranulocytosis

Drugs CCCrush, Myeloblasts, and Promyelocytes
dapsone, clozapine, carbamazepine, colchicine, methimazole, propylthiouracil

37

Heme: 6 Ds that cause aplastic anemia

can't make new blood cells properly
carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, propylthiouracil

38

Heme: 2 Ds that cause direct-coombs positive hemolytic anemia

methyldopa, penicillin

39

Heme: 1 D that causes gray baby syndrome

chloramphenicol

40

Heme: 7 Ds that cause hemolysis in G6PD def

Hemolysis IS D PAIN
INH, sulfonamides, dapsone, primaquine, asprin, ibuprofen, nitrofurantoin

41

Heme: 3 Ds that causes megaloblastic anemia

having a blast with PMS
phenytoin, methotrexate, sulfa drugs

42

Heme: 2 Ds that cause thrombocytopenia

heparine, cimetidine

43

Heme: 2 Ds that cause thrombotic compications

OCPs (estrogen)

44

Neuro: 2 Ds that cause cinchonism

quinidine, quinine

45

Neuro: 3 Ds that cause Parkinson like syndrome

cogwheel rigidity of ARM
antipsychotics, reserpine, metoclopramide

46

Neuro: 6 drugs that cause seizures

with seizures I BITE My toungue
INH (vit B6 def), bupropin, imipenem/cilastatin, tramadol, enflurane, metclopramide

47

Neuro: 2 Ds that cause tardive dsykinesia

antipsychotics, metoclopramide

48

Musculo/Skin/Connective Tissue: name 2 agents take can cause fat redistribution

protease inhibitors, glucocorticoids (Fat PiG)

49

M/S/C: name 4 drugs that can cause gingival hyperplasia

phenytoin, verpamil, cyclosporine, nifedipine

50

M/S/C: name 5 drugs that can cause hyperuricemia (gout)

Painful Tophi and Feet Need Care
Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine

51

M/S/C: 8 drugs that can cause myopathy

fibrates, niacin, colchicine, hydroxychloroquine, interferon-alpha, penicillamine, statins, glucocorticoids

52

M/S/C: 3 drugs that can cause osteoporosis

corticosteroids, heparin

53

M/S/C: name 4 drugs that can cause photosensitivity

SAT For Photo
Sulfonamides, Amiodarone, Tetracyclines, 5-FU

54

M/S/C: name 9 rugs that can cause rash Steven-Johnson Syndrome

Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin
anti-epileptic drugs (ethosuximide, carbamezapine, lamotrigine, phenytoin, phenobarbital) Allopurinol, Sulfa drugs, Penicillin

55

M/S/C: 6 drugs that can cause SLE-like syndrome

having lupus is SHIPP-E
sulfa drugs, hydrazaline, INH, Procainamide, Phenytoin, Etanercept

56

M/S/C: drug that causes teeth discoloration

tetracycline

57

M/S/C: drug that can lead to tendonitis, tendon rupture, and cartilage damage

fluoroquinolones

58

renal/GI: name 2 drugs that can diabetes insipidus

lithiiium, demeclocyline

59

renal/GI: name 1 drug that can cause Fanconi syndrome

expired tetracycline

60

renal/GI: name 2 drugs that can cause hemorrhagic cystitis, how to you prevent it?

cyclophosphamide, and ifosfamide. give mensa

61

renal/GI: name 3 drugs that cause interstitial nephritis

methicillin, NSAIDs, furoseminde

62

renal/GI: 3 drugs that cause SIADH

can't concentration serum sodium
Carbamezepine, Cyclophosphamide, SSRIs

63

pul: 1 drug that causes dry cough

ACE inhbitors

64

pul: 4 drugs that cause pulmonary fibrosis

breathing air badly form medications
bleomycin, amiodarone, busulfan, methotrexate

65

multiorgan: name 4 drugs that cause antimuscarinic

atropine, TCAs, H1-blockers, antipsychotics

66

multiorgan: 5 drugs that can cause disulfarin-like reaction

metronidazole, certain cephalopsorins, griseofulvin, procarbazine, 1st line sulfonyureas

67

multiorgran: 4 drugs that cause nephrotoxicity/otoxicity

aminoglycosides, vancomyocin, loop diuretics, cisplatin

68

P-450 inducers

chronic alcohol abuse, modafinil, St.John's wort, phenytoin, phenobarbital, nevirapine, rifampin, griseofulvin, carabamazepine. Chronic alcholic Mona Steals Phen-Phen and Never Refuses Greasy, Carbs.

69

P-450 Substrates

anti-epileptics, antidepressants, antipsychotics, anesthetics, theophyliine, warfain, statins, OCPs
Always, Always, Always, Always, Think When Starting Overs

70

P-450 inhibitors

acute alcohol abuse, gemfibrozil, ciprofloxacin, isoniazid, grapefruit juice, quinidine, amiodarone, ketoconazole, macrolides, sulfonamides, cimetidine, ritonavir,
A cute Gentleman "Cipped" Iced grapefruit juice quickly And Kept Munching On Soft Cinammon Rolls

71

Name 8 sulfa drugs

Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine, Sulfonylureas Popular FACTSSS

72

pts with sulfa allergies may develop 7 symptoms (severity of symptoms)

fever, urinary tract infection, Steven-Johnson Syndrome, hemolytic anemia, thrombocytopenia, agranulocytosis, and urticaria (hives)
range from mild to life threatening