Flashcards in Pharm Small Group - Infectious Diseases 2 Deck (12):
If a C.Difficile patient is unable to tolerate by mouth medications, what are the other options and why?
IV Metronidazole may be given, however IV Vanc is ineffective.
While confirmation of the organism is being performed, which empirical therapy should be instituted?
- Vancomycin + gentamicin
- Rifampin can be added for treatment of endocarditis in the presence of a prosthetic heart valve.
What would you give infective endocarditis patients empirically who have intolerance to vancomcin or resistant organisms?
In all regimens, what is the replacement for patients with penicillin allergy?
What is the main indication of aminoglycosides?
mostly Aerobic gram negatives
Why are b-lactam antibiotics often combined with aminoglycosides?
Extend coverage to include potential gram positive pathogens and to take advantage of the synergism between the two classes of drugs:
-b-lactam inhibit cell wall synthesis and thefore increase permeability of bacterium to aminoglycosides.
Why should aminoglycosides never be mixed in the same solution with penicillins?
Penicillins inactivate aminoglycosides to a certain degree.
What are the potential adverse effects of aminoglycosides?
-Nephrotoxicity (reversible): 5-7 days after therapy
What is the standard regimen recommended for endocarditis prophylaxis during oral-dental or respiratory tract procedures
What is the regimen recommended in patients allergic to oral penicillin for endocarditis prophylaxis during oral-dental or respiratory tract procedures
-Azithromycin or clarithromycin
What is the regimen recommended in patients unable to take oral medication for endocarditis prophylaxis during oral-dental or respiratory tract procedures
Ampicillin IV or IM