Pharm Small Group - Infectious Diseases 2 Flashcards Preview

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Flashcards in Pharm Small Group - Infectious Diseases 2 Deck (12):
1

If a C.Difficile patient is unable to tolerate by mouth medications, what are the other options and why?

IV Metronidazole may be given, however IV Vanc is ineffective.

2

While confirmation of the organism is being performed, which empirical therapy should be instituted?

- Vancomycin + gentamicin
- Rifampin can be added for treatment of endocarditis in the presence of a prosthetic heart valve.

3

What would you give infective endocarditis patients empirically who have intolerance to vancomcin or resistant organisms?

-Linezolid or
-Daptomycin

4

In all regimens, what is the replacement for patients with penicillin allergy?

Vancomycin

5

What is the main indication of aminoglycosides?

mostly Aerobic gram negatives

6

Why are b-lactam antibiotics often combined with aminoglycosides?

Extend coverage to include potential gram positive pathogens and to take advantage of the synergism between the two classes of drugs:

-b-lactam inhibit cell wall synthesis and thefore increase permeability of bacterium to aminoglycosides.

7

Why should aminoglycosides never be mixed in the same solution with penicillins?

Penicillins inactivate aminoglycosides to a certain degree.

8

What are the potential adverse effects of aminoglycosides?

-Nephrotoxicity (reversible): 5-7 days after therapy
-Ototoxicity (irreversible)

9

What is the standard regimen recommended for endocarditis prophylaxis during oral-dental or respiratory tract procedures

Amoxicillin

10

What is the regimen recommended in patients allergic to oral penicillin for endocarditis prophylaxis during oral-dental or respiratory tract procedures

-Clindamycin

-Cephalexin

-Azithromycin or clarithromycin

11

What is the regimen recommended in patients unable to take oral medication for endocarditis prophylaxis during oral-dental or respiratory tract procedures

Ampicillin IV or IM

12

What is the regimen recommended in patients allergic to penicillin for endocarditis prophylaxis during oral-dental or respiratory tract procedures

Clindamycin IV

or

Cefazolin IV