Flashcards in Pharm2- Ethanol/DrugsofAbuse Deck (35):
? is required for activity of alc dehydrogenase?
rate limiting step?
NAD+ >>> NADH
chief cause of met d/o in alc?
excess of NADH in liver
asian gene mutation
same actions as disulfiram- increase in ? due to ?
ALDH, low affinity for NAD+
w/ large qty of alc- another p/w becomes available? produces ? & ? w/ drugs
MEOS (microsomal ethanol oxidizing system), free radicals, cross tol/interactions
inc GABA, opioids
dec ? and ?
NMDA rec fxn- blackouts, Ca influx
hyperestroginization in males (dec. test)
prevents alc-related seizures?
48-72h post drinking- autonomic instability, disorientation, and ? called?
? can return liver with high trigly and inc NADH to normal
high cal diet
alc inc risk of pulm dz - ? and ?
short term tx, can dec consumption in heavy drinkers, opioid ant at U rec?
GABAb agoniest that dec cravings in alc?
MC benzos for alc w/drawal?
a/e of methanol poisoning?
blocks DAT and NET?
REVERSES action of DAT and NET? also bind to VMAT
dental probs, bruxism?
meth vs. cocaine (3)
increases release AND blocks uptake
cold turkey, kicking the habit?
very long half life, gradual onset, opioid tx?
PARTIAL agonist at mu and nociceptin
ANTAGONIST at kappa
opioid antagonist at u rec; no euphoria- poor compliance
dissociative; noncompetitive NMDA antagonists?
NMDA antagonist and sigmoid rec agonist?
inactogenic, ALL serotonin related?
prevents reuptake and reverses SERT actions via phosphorylation
-binds to ?
-toxic: ?, ?
MDMA - ecstasy
dehydration (hyponatremia), hyperthermia
no addiction but rapid tolerance ?
halluc- bind at 5HT1a also, intense emotional swings, HPPD- flashbacks, abortion-inducing?
spineless cactus- mescaline?
peyote; can have fetal abn
mushrooms; tea or foods, 6 h, relaxation, weakness, ataxia, pupil dilation, N/V
THC causes disinhibition of ?
weed tx? 3
decreases IOP, inc appetite for chemo, neuropathic pain
NABIlone, droNABInol tx?
AIDS, N/V in chemo, fibromyalgia (nabilone)
MAOI that inc DA/NE/5-HT; release Epi and glucose; dec insulin output?