Pharm2- Ethanol/DrugsofAbuse Flashcards Preview

Pharmacology > Pharm2- Ethanol/DrugsofAbuse > Flashcards

Flashcards in Pharm2- Ethanol/DrugsofAbuse Deck (35):
1

? is required for activity of alc dehydrogenase?

NAD

2

rate limiting step?

NAD+ >>> NADH

3

chief cause of met d/o in alc?

excess of NADH in liver

4

asian gene mutation
same actions as disulfiram- increase in ? due to ?

ALDH, low affinity for NAD+

5

w/ large qty of alc- another p/w becomes available? produces ? & ? w/ drugs

MEOS (microsomal ethanol oxidizing system), free radicals, cross tol/interactions

6

ethanol actions
inc GABA, opioids
dec ? and ?

NMDA rec fxn- blackouts, Ca influx

7

hepatic changes?
sexual?

none ACUTE
hyperestroginization in males (dec. test)

8

prevents alc-related seizures?

lorazepam

9

48-72h post drinking- autonomic instability, disorientation, and ? called?

hallucinations
deilirium tremens

10

? can return liver with high trigly and inc NADH to normal

high cal diet

11

alc inc risk of pulm dz - ? and ?

ARDS, pneumonia

12

short term tx, can dec consumption in heavy drinkers, opioid ant at U rec?

naltrexone

13

GABAb agoniest that dec cravings in alc?

baclofen

14

MC benzos for alc w/drawal?

diazepam
chlordiazepoxide

15

a/e of methanol poisoning?

severe acidosis
retinal damage/blindness

16

blocks DAT and NET?

cocaine

17

REVERSES action of DAT and NET? also bind to VMAT

amphetamines

18

dental probs, bruxism?

amphetamines

19

meth vs. cocaine (3)

man made
longer high
increases release AND blocks uptake

20

cold turkey, kicking the habit?

opioid s/e

21

very long half life, gradual onset, opioid tx?

methadone

22

opiod tx:
PARTIAL agonist at mu and nociceptin
ANTAGONIST at kappa

bupenORPHINE

23

opioid antagonist at u rec; no euphoria- poor compliance

naltrexone

24

dissociative; noncompetitive NMDA antagonists?

ketamine, PCP

25

NMDA antagonist and sigmoid rec agonist?

PCP

26

inactogenic, ALL serotonin related?
prevents reuptake and reverses SERT actions via phosphorylation
-binds to ?
-toxic: ?, ?

MDMA - ecstasy
5HT1
dehydration (hyponatremia), hyperthermia

27

no addiction but rapid tolerance ?
main target?

hallucinogens
5HT2a

28

halluc- bind at 5HT1a also, intense emotional swings, HPPD- flashbacks, abortion-inducing?

LSD

29

spineless cactus- mescaline?

peyote; can have fetal abn

30

mushrooms; tea or foods, 6 h, relaxation, weakness, ataxia, pupil dilation, N/V

psilocybin

31

THC causes disinhibition of ?

dopa neurons

32

weed tx? 3

decreases IOP, inc appetite for chemo, neuropathic pain

33

NABIlone, droNABInol tx?

AIDS, N/V in chemo, fibromyalgia (nabilone)

34

MAOI that inc DA/NE/5-HT; release Epi and glucose; dec insulin output?

tobacco

35

tobacco tx:
-dopa & NE reuptake inh?
-nicotine rec agonist on dopa neuron in VTA; stim rec w/o release of dopa; impaired driving and increased suicide ideation

buproprion
varenicline