Flashcards in Pharm2- Ethanol/DrugsofAbuse Deck (35):
1
? is required for activity of alc dehydrogenase?
NAD
2
rate limiting step?
NAD+ >>> NADH
3
chief cause of met d/o in alc?
excess of NADH in liver
4
asian gene mutation
same actions as disulfiram- increase in ? due to ?
ALDH, low affinity for NAD+
5
w/ large qty of alc- another p/w becomes available? produces ? & ? w/ drugs
MEOS (microsomal ethanol oxidizing system), free radicals, cross tol/interactions
6
ethanol actions
inc GABA, opioids
dec ? and ?
NMDA rec fxn- blackouts, Ca influx
7
hepatic changes?
sexual?
none ACUTE
hyperestroginization in males (dec. test)
8
prevents alc-related seizures?
lorazepam
9
48-72h post drinking- autonomic instability, disorientation, and ? called?
hallucinations
deilirium tremens
10
? can return liver with high trigly and inc NADH to normal
high cal diet
11
alc inc risk of pulm dz - ? and ?
ARDS, pneumonia
12
short term tx, can dec consumption in heavy drinkers, opioid ant at U rec?
naltrexone
13
GABAb agoniest that dec cravings in alc?
baclofen
14
MC benzos for alc w/drawal?
diazepam
chlordiazepoxide
15
a/e of methanol poisoning?
severe acidosis
retinal damage/blindness
16
blocks DAT and NET?
cocaine
17
REVERSES action of DAT and NET? also bind to VMAT
amphetamines
18
dental probs, bruxism?
amphetamines
19
meth vs. cocaine (3)
man made
longer high
increases release AND blocks uptake
20
cold turkey, kicking the habit?
opioid s/e
21
very long half life, gradual onset, opioid tx?
methadone
22
opiod tx:
PARTIAL agonist at mu and nociceptin
ANTAGONIST at kappa
bupenORPHINE
23
opioid antagonist at u rec; no euphoria- poor compliance
naltrexone
24
dissociative; noncompetitive NMDA antagonists?
ketamine, PCP
25
NMDA antagonist and sigmoid rec agonist?
PCP
26
inactogenic, ALL serotonin related?
prevents reuptake and reverses SERT actions via phosphorylation
-binds to ?
-toxic: ?, ?
MDMA - ecstasy
5HT1
dehydration (hyponatremia), hyperthermia
27
no addiction but rapid tolerance ?
main target?
hallucinogens
5HT2a
28
halluc- bind at 5HT1a also, intense emotional swings, HPPD- flashbacks, abortion-inducing?
LSD
29
spineless cactus- mescaline?
peyote; can have fetal abn
30
mushrooms; tea or foods, 6 h, relaxation, weakness, ataxia, pupil dilation, N/V
psilocybin
31
THC causes disinhibition of ?
dopa neurons
32
weed tx? 3
decreases IOP, inc appetite for chemo, neuropathic pain
33
NABIlone, droNABInol tx?
AIDS, N/V in chemo, fibromyalgia (nabilone)
34
MAOI that inc DA/NE/5-HT; release Epi and glucose; dec insulin output?
tobacco
35