Flashcards in Pharm2TCN/Macrolides/A/G Deck (40)
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1
TCNs primarily for infix that can't be tx with ?
B lactams
2
tcn 1st line for helicobacter?
tetra, also tx acne
3
tigecycline can tx ? which is ?
MDR gram pos cocci, bac resistant to TCN
also Tx MRSA, VRSA, VRE, bacteroides
4
TCN resistance via?
efflux pump
5
tcn forms ? with cations so oral absorptions is decreased with ingestion of ? and ?
chelates
dairy foods, antacids (Ca, Mg, Al, Fe)
6
TCN- CI in?
-s/e ?
-expired/outdated drugs?
pregnancy, breastfeeding, children <8
GI, phototoxicity, esophageal ulcers
Fanconi syndrome
7
TCN
SOA:
G- aerobes, G- and + anaerobes>> BROADEST
DOES NOT Tx G+ aerobes but tigecycline will!!
8
Mino eradicates ? and Tx? (2)
-concentrates in ?
N. meningitis (carrier), Nocardia, acne
-tears & saliva
9
general s/e of tcn?
fetal teeth discoloration, bone formation
10
macrolide- Pen G sub in allergy?
erythro
11
1st line for chanchroid & diphtheria?
erythro
12
clarithro- more ? activity; 1st line for ?
IC activity, MAI complex
13
azithro- more activity against ? and ?
H&M; haemophilus, moraxella
14
macrolides safe in?
pregnancy, children
15
macrolides do not tx?
meningitis (don't cross BBB)
16
macrolide resistance:
G+?
G-?
altered target site
inactivated by plasmid-associated esterase
17
ALL macrolides tx?
ALL are 1st line for?
pen-resistant S. pyogenes
diphtheria
18
clarithromycin ? w/ food
increases absorption (erythro & azithro opposite)
19
1st line for MAI, chlamydia pneum, diphtheria?
clarithro
20
DOC - 1 dose for trachomatis
1st line diphtheria, legionnaires
azithro
21
strept pneum resistant to ALL macrolides- Tx w/ ?
telithromycin (ketolide)
22
telithro binds to ?
2 sites on 50s
23
telithro:
only tx ? bc of liver damage
s/e?
CI?
CAP (resistant to macrolides)
jaundice, PROLONGED QT
<18
24
a/g are bacterioCIDAL b/c they ?
inhibit protein synthesis IRREVERSIBLY
25
a/g
SOA: all ? but NO ANAEROBES
limited G+ activity
gram neg bacilli
26
a/g can tx ? when given w/ CWI!
meningitis (a/g don't cross BBB)
27
DOC for plague, tularemia
streptomycin
w/ yersinia aka black death/plague- +/-TCN
28
a/g- gentamicin = exception bc?
>DOC for ? and ? from ? in combo w/
>infx assoc w/ ?
>also first line for MENINGITIS and bacteremia from ? or ? and can be employed with ? or ?
-tx gram pos!
-bacteremia, endocarditis; enterococcus; ampicillin, pen G, vancomycin
-burns
-strep agalactiae, listeria; penG, ampicillin
29
tx brucella ?
genta & doxy
30
