Pharm2TCN/Macrolides/A/G Flashcards Preview

Pharmacology > Pharm2TCN/Macrolides/A/G > Flashcards

Flashcards in Pharm2TCN/Macrolides/A/G Deck (40):
1

TCNs primarily for infix that can't be tx with ?

B lactams

2

tcn 1st line for helicobacter?

tetra, also tx acne

3

tigecycline can tx ? which is ?

MDR gram pos cocci, bac resistant to TCN
also Tx MRSA, VRSA, VRE, bacteroides

4

TCN resistance via?

efflux pump

5

tcn forms ? with cations so oral absorptions is decreased with ingestion of ? and ?

chelates
dairy foods, antacids (Ca, Mg, Al, Fe)

6

TCN- CI in?
-s/e ?
-expired/outdated drugs?

pregnancy, breastfeeding, children <8
GI, phototoxicity, esophageal ulcers
Fanconi syndrome

7

TCN
SOA:

G- aerobes, G- and + anaerobes>> BROADEST
DOES NOT Tx G+ aerobes but tigecycline will!!

8

Mino eradicates ? and Tx? (2)
-concentrates in ?

N. meningitis (carrier), Nocardia, acne
-tears & saliva

9

general s/e of tcn?

fetal teeth discoloration, bone formation

10

macrolide- Pen G sub in allergy?

erythro

11

1st line for chanchroid & diphtheria?

erythro

12

clarithro- more ? activity; 1st line for ?

IC activity, MAI complex

13

azithro- more activity against ? and ?

H&M; haemophilus, moraxella

14

macrolides safe in?

pregnancy, children

15

macrolides do not tx?

meningitis (don't cross BBB)

16

macrolide resistance:
G+?
G-?

altered target site
inactivated by plasmid-associated esterase

17

ALL macrolides tx?
ALL are 1st line for?

pen-resistant S. pyogenes
diphtheria

18

clarithromycin ? w/ food

increases absorption (erythro & azithro opposite)

19

1st line for MAI, chlamydia pneum, diphtheria?

clarithro

20

DOC - 1 dose for trachomatis
1st line diphtheria, legionnaires

azithro

21

strept pneum resistant to ALL macrolides- Tx w/ ?

telithromycin (ketolide)

22

telithro binds to ?

2 sites on 50s

23

telithro:
only tx ? bc of liver damage
s/e?
CI?

CAP (resistant to macrolides)
jaundice, PROLONGED QT
<18

24

a/g are bacterioCIDAL b/c they ?

inhibit protein synthesis IRREVERSIBLY

25

a/g
SOA: all ? but NO ANAEROBES
limited G+ activity

gram neg bacilli

26

a/g can tx ? when given w/ CWI!

meningitis (a/g don't cross BBB)

27

DOC for plague, tularemia

streptomycin
w/ yersinia aka black death/plague- +/-TCN

28

a/g- gentamicin = exception bc?
>DOC for ? and ? from ? in combo w/
>infx assoc w/ ?
>also first line for MENINGITIS and bacteremia from ? or ? and can be employed with ? or ?

-tx gram pos!
-bacteremia, endocarditis; enterococcus; ampicillin, pen G, vancomycin
-burns
-strep agalactiae, listeria; penG, ampicillin

29

tx brucella ?

genta & doxy

30

1st line for bacteremia & pneum & UTIs due to pseudomonas?

tobramycin

31

broadest spectrum a/g
resistant to inactivating enzymes
tx nosocomial infx i.e. enterobacter, serratia that are resistant to ? and ?

amikacin
genta, tobra

32

? give orally for bowel sterilization & surgical prophy for hepatic coma
s/e?

neomycin
NM paralysis

33

only for severe infix
back up for rickettsia and psitticosis

chloramphenicol

34

prophy endo w/ pcn allergy

clindamycin

35

fusobacterium givngivitis?

clindamycin

36

clindamycin does NOT treat ? >>narrow spectrum even though it treats ?
a/e?
concentrates in?

G- aerobes
G+ aerobes, G+ and - anaerobes
pseudo. colitis
bone! (like cefazolin)

37

inhibits bacterial isoleucyl transfer-RNA synthase?
Bacteriocidal, Tx skin lesions and ? (G+cocci)
eradication of ? in health care workers

mupirocin
impetigo (topical)
MRSA (intranasally)

38

related to a/g, bind to 30s, 3rd line treatment of gonorrhea

spectinomycin

39

interacts w/ 23s rRNA and inh 50s?
SOA?

linezolid (zyvox)
G+ cocci, includes pneumonia & Ent. facials

40

streptogramin-synercid
doesn't treat?
only E. faecium
toxicity?

pneum
infusion phlebitis