Pharm2TCN/Macrolides/A/G

Question 1

TCNs primarily for infix that can’t be tx with ?

Answer 1

B lactams

Question 2

tcn 1st line for helicobacter?

Answer 2

tetra, also tx acne

Question 3

tigecycline can tx ? which is ?

Answer 3

MDR gram pos cocci, bac resistant to TCN

also Tx MRSA, VRSA, VRE, bacteroides

Question 4

TCN resistance via?

Answer 4

efflux pump

Question 5

tcn forms ? with cations so oral absorptions is decreased with ingestion of ? and ?

Answer 5

chelates

dairy foods, antacids (Ca, Mg, Al, Fe)

Question 6

TCN- CI in?

• s/e ?
• expired/outdated drugs?

Answer 6

pregnancy, breastfeeding, children <8
GI, phototoxicity, esophageal ulcers
Fanconi syndrome

Question 7

TCN

SOA:

Answer 7

G- aerobes, G- and + anaerobes» BROADEST

DOES NOT Tx G+ aerobes but tigecycline will!!

Question 8

Mino eradicates ? and Tx? (2)

-concentrates in ?

Answer 8

N. meningitis (carrier), Nocardia, acne

-tears & saliva

Question 9

general s/e of tcn?

Answer 9

fetal teeth discoloration, bone formation

Question 10

macrolide- Pen G sub in allergy?

Answer 10

erythro

Question 11

1st line for chanchroid & diphtheria?

Answer 11

erythro

Question 12

clarithro- more ? activity; 1st line for ?

Answer 12

IC activity, MAI complex

Question 13

azithro- more activity against ? and ?

Answer 13

H&M; haemophilus, moraxella

Question 14

macrolides safe in?

Answer 14

pregnancy, children

Question 15

macrolides do not tx?

Answer 15

meningitis (don’t cross BBB)

Question 16

macrolide resistance:
G+?
G-?

Answer 16

altered target site

inactivated by plasmid-associated esterase

Question 17

ALL macrolides tx?

ALL are 1st line for?

Answer 17

pen-resistant S. pyogenes

diphtheria

Question 18

clarithromycin ? w/ food

Answer 18

increases absorption (erythro & azithro opposite)

Question 19

1st line for MAI, chlamydia pneum, diphtheria?

Answer 19

clarithro

Question 20

DOC - 1 dose for trachomatis

1st line diphtheria, legionnaires

Answer 20

azithro

Question 21

strept pneum resistant to ALL macrolides- Tx w/ ?

Answer 21

telithromycin (ketolide)

Question 22

telithro binds to ?

Answer 22

2 sites on 50s

Question 23

telithro:
only tx ? bc of liver damage
s/e?
CI?

Answer 23

CAP (resistant to macrolides)
jaundice, PROLONGED QT
<18

Question 24

a/g are bacterioCIDAL b/c they ?

Answer 24

inhibit protein synthesis IRREVERSIBLY

Question 25

a/g SOA: all ? but NO ANAEROBES limited G+ activity

Answer 25

gram neg bacilli

Question 26

a/g can tx ? when given w/ CWI!

Answer 26

meningitis (a/g don't cross BBB)

Question 27

DOC for plague, tularemia

Answer 27

streptomycin | w/ yersinia aka black death/plague- +/-TCN

Question 28

a/g- gentamicin = exception bc? >DOC for ? and ? from ? in combo w/ >infx assoc w/ ? >also first line for MENINGITIS and bacteremia from ? or ? and can be employed with ? or ?

Answer 28

- tx gram pos! - bacteremia, endocarditis; enterococcus; ampicillin, pen G, vancomycin - burns - strep agalactiae, listeria; penG, ampicillin

Question 29

tx brucella ?

Answer 29

genta & doxy

Question 30

1st line for bacteremia & pneum & UTIs due to pseudomonas?

Answer 30

tobramycin

Question 31

broadest spectrum a/g resistant to inactivating enzymes tx nosocomial infx i.e. enterobacter, serratia that are resistant to ? and ?

Answer 31

amikacin | genta, tobra

Question 32

? give orally for bowel sterilization & surgical prophy for hepatic coma s/e?

Answer 32

neomycin | NM paralysis

Question 33

only for severe infix | back up for rickettsia and psitticosis

Answer 33

chloramphenicol

Question 34

prophy endo w/ pcn allergy

Answer 34

clindamycin

Question 35

fusobacterium givngivitis?

Answer 35

clindamycin

Question 36

clindamycin does NOT treat ? >>narrow spectrum even though it treats ? a/e? concentrates in?

Answer 36

G- aerobes G+ aerobes, G+ and - anaerobes pseudo. colitis bone! (like cefazolin)

Question 37

inhibits bacterial isoleucyl transfer-RNA synthase? Bacteriocidal, Tx skin lesions and ? (G+cocci) eradication of ? in health care workers

Answer 37

mupirocin impetigo (topical) MRSA (intranasally)

Question 38

related to a/g, bind to 30s, 3rd line treatment of gonorrhea

Answer 38

spectinomycin

Question 39

interacts w/ 23s rRNA and inh 50s? | SOA?

Answer 39

linezolid (zyvox) | G+ cocci, includes pneumonia & Ent. facials

Question 40

streptogramin-synercid doesn't treat? only E. faecium toxicity?

Answer 40

pneum | infusion phlebitis