Flashcards in Pharm2TCN/Macrolides/A/G Deck (40):
TCNs primarily for infix that can't be tx with ?
tcn 1st line for helicobacter?
tetra, also tx acne
tigecycline can tx ? which is ?
MDR gram pos cocci, bac resistant to TCN
also Tx MRSA, VRSA, VRE, bacteroides
TCN resistance via?
tcn forms ? with cations so oral absorptions is decreased with ingestion of ? and ?
dairy foods, antacids (Ca, Mg, Al, Fe)
TCN- CI in?
pregnancy, breastfeeding, children <8
GI, phototoxicity, esophageal ulcers
G- aerobes, G- and + anaerobes>> BROADEST
DOES NOT Tx G+ aerobes but tigecycline will!!
Mino eradicates ? and Tx? (2)
-concentrates in ?
N. meningitis (carrier), Nocardia, acne
-tears & saliva
general s/e of tcn?
fetal teeth discoloration, bone formation
macrolide- Pen G sub in allergy?
1st line for chanchroid & diphtheria?
clarithro- more ? activity; 1st line for ?
IC activity, MAI complex
azithro- more activity against ? and ?
H&M; haemophilus, moraxella
macrolides safe in?
macrolides do not tx?
meningitis (don't cross BBB)
altered target site
inactivated by plasmid-associated esterase
ALL macrolides tx?
ALL are 1st line for?
pen-resistant S. pyogenes
clarithromycin ? w/ food
increases absorption (erythro & azithro opposite)
1st line for MAI, chlamydia pneum, diphtheria?
DOC - 1 dose for trachomatis
1st line diphtheria, legionnaires
strept pneum resistant to ALL macrolides- Tx w/ ?
telithro binds to ?
2 sites on 50s
only tx ? bc of liver damage
CAP (resistant to macrolides)
jaundice, PROLONGED QT
a/g are bacterioCIDAL b/c they ?
inhibit protein synthesis IRREVERSIBLY
SOA: all ? but NO ANAEROBES
limited G+ activity
gram neg bacilli
a/g can tx ? when given w/ CWI!
meningitis (a/g don't cross BBB)
DOC for plague, tularemia
w/ yersinia aka black death/plague- +/-TCN
a/g- gentamicin = exception bc?
>DOC for ? and ? from ? in combo w/
>infx assoc w/ ?
>also first line for MENINGITIS and bacteremia from ? or ? and can be employed with ? or ?
-tx gram pos!
-bacteremia, endocarditis; enterococcus; ampicillin, pen G, vancomycin
-strep agalactiae, listeria; penG, ampicillin
tx brucella ?
genta & doxy
1st line for bacteremia & pneum & UTIs due to pseudomonas?
broadest spectrum a/g
resistant to inactivating enzymes
tx nosocomial infx i.e. enterobacter, serratia that are resistant to ? and ?
? give orally for bowel sterilization & surgical prophy for hepatic coma
only for severe infix
back up for rickettsia and psitticosis
prophy endo w/ pcn allergy
clindamycin does NOT treat ? >>narrow spectrum even though it treats ?
G+ aerobes, G+ and - anaerobes
bone! (like cefazolin)
inhibits bacterial isoleucyl transfer-RNA synthase?
Bacteriocidal, Tx skin lesions and ? (G+cocci)
eradication of ? in health care workers
related to a/g, bind to 30s, 3rd line treatment of gonorrhea
interacts w/ 23s rRNA and inh 50s?
G+ cocci, includes pneumonia & Ent. facials