Pharma/Physiology Flashcards
what is the most common excitatory neurotransmitter in the CNS?
glutamate
what is the most common inhibitory neurotransmitter in the CNS?
GABA/glycine
does sodium ion entry into a cell have an inhibitory or excitatory effect?
excitatory
does calcium ion entry into a cell have an inhibitory or excitatory effect?
excitatory
does chloride ion entry into a cell have an inhibitory or excitatory effect?
inhbitory
does potassium ion exit from a cell have an inhibitory or excitatory effect?
inhibitory
where do ionotropic receptors lie in relation to the channel they are gating?
Receptor is part of the channel itself
where do metabotropic receptors lie in relation to the channel they are gating?
receptor is at a distinct site from channel
what ions do non-NMDA ionotropic receptors control?
Na+ and K+
what ions do NMDA ionotropic receptors control?
Na+, Ca2+ and K+
what ion channel do ionotropic GABAa receptors operate?
Cl-
what ion channel do metabotropic GABAb receptors operate?
K+
what ion channel do ionotropic glycine receptors operate?
Cl-
are ionotropic or metabotropic faster at gating ion channels?
ionotropic (ms)
metabotropic tens of ms
what types of sensation does the somatosensory NOT mediate?
visual auditory gustatory olfactory vestibular