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Flashcards in Pharma Product Rollout Deck (10):
1

What disorders is Oncocytin used to treat?

  • Advanced nonsquamous non–small cell lung cancer (NSCLC) in combination with carboplatin and paclitaxel in people who have not received chemotherapy for their advanced disease
  • Metastatic kidney cancer (mRCC) when used with interferon alfa
  • Advanced cervical cancer (CC) in combination with paclitaxel and cisplatin or paclitaxel and topotecan, is approved to treat persistent, recurrent, or metastatic cancer of the cervix

2

What is the chemical makeup of Oncocytin?

Sildenafil citrate is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate and has the following structural formula:

3

At what stage is Oncocytin usually administered?

Typically in advanced cancers, after an initial first-line treatment containing fluoropyrimidine-based (combined with irinotecan or oxaliplatin) chemotherapy

4

How is Oncocytin administered?

Intravenously, with a combination of saline solution and occasionally with other chemotherapy drugs such methotrexate and cytarabine

5

What are the characteristics of Nonsquamous non–small cell lung cancer (NSCLC), as opposed to other lung cancers?

Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC).

  • NSCLC accounts for about 85% of all lung cancers.
  • As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small cell carcinoma.
  • When possible, they are primarily treated by surgical resection with curative intent, although chemotherapy is increasingly being used both pre-operatively (neoadjuvant chemotherapy) and post-operatively (adjuvant chemotherapy).

6

What are Oncocytin's main competitors, and how is Oncocytin better?

  • Cancerol -- Generic chemo cocktail that is not specific to NSCLC, mRCC, or CC, thus often damaging excessive surrounding tissue
  • Tumerifin -- Only 20% effective in clinical trials, vs. Oncocytin's 60% effectiveness
  • Metasticil -- Nausea side effects are particularly accute and persist for 70% longer than with Oncocytin

7

What are the most common side effects of Oncocytin?

  • High blood pressure
  • Too much protein in the urine
  • Nosebleeds
  • Rectal bleeding
  • Back pain
  • Headache
  • Taste change
  • Dry skin
  • Inflammation of the skin
  • Inflammation of the nose
  • Watery eyes

8

What types of people should not take Oncocytin?

Anyone undergoing surgery, pregnant (or possibly pregnant), or breastfeeding

9

Are there any generic alternatives to Oncocytin?

No, Oncocytin is still protected by patent until 2026.

However, there are two counterfeit drugs -- Oncocytol and Oncolin -- that are starting to circulate, and doctors should beware

10

How can you validate the authenticity of Oncocytin?

Oncocytin should always be distributed in a sealed bottle with the company seal, and should only be purchased through certified company representatives