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Flashcards in Pharma Product Rollout Deck (10)

What disorders is Oncocytin used to treat?

  • Advanced nonsquamous non–small cell lung cancer (NSCLC) in combination with carboplatin and paclitaxel in people who have not received chemotherapy for their advanced disease
  • Metastatic kidney cancer (mRCC) when used with interferon alfa
  • Advanced cervical cancer (CC) in combination with paclitaxel and cisplatin or paclitaxel and topotecan, is approved to treat persistent, recurrent, or metastatic cancer of the cervix


What is the chemical makeup of Oncocytin?

Sildenafil citrate is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate and has the following structural formula:


At what stage is Oncocytin usually administered?

Typically in advanced cancers, after an initial first-line treatment containing fluoropyrimidine-based (combined with irinotecan or oxaliplatin) chemotherapy


How is Oncocytin administered?

Intravenously, with a combination of saline solution and occasionally with other chemotherapy drugs such methotrexate and cytarabine


What are the characteristics of Nonsquamous non–small cell lung cancer (NSCLC), as opposed to other lung cancers?

Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC).

  • NSCLC accounts for about 85% of all lung cancers.
  • As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small cell carcinoma.
  • When possible, they are primarily treated by surgical resection with curative intent, although chemotherapy is increasingly being used both pre-operatively (neoadjuvant chemotherapy) and post-operatively (adjuvant chemotherapy).


What are Oncocytin's main competitors, and how is Oncocytin better?

  • Cancerol -- Generic chemo cocktail that is not specific to NSCLC, mRCC, or CC, thus often damaging excessive surrounding tissue
  • Tumerifin -- Only 20% effective in clinical trials, vs. Oncocytin's 60% effectiveness
  • Metasticil -- Nausea side effects are particularly accute and persist for 70% longer than with Oncocytin


What are the most common side effects of Oncocytin?

  • High blood pressure
  • Too much protein in the urine
  • Nosebleeds
  • Rectal bleeding
  • Back pain
  • Headache
  • Taste change
  • Dry skin
  • Inflammation of the skin
  • Inflammation of the nose
  • Watery eyes


What types of people should not take Oncocytin?

Anyone undergoing surgery, pregnant (or possibly pregnant), or breastfeeding


Are there any generic alternatives to Oncocytin?

No, Oncocytin is still protected by patent until 2026.

However, there are two counterfeit drugs -- Oncocytol and Oncolin -- that are starting to circulate, and doctors should beware


How can you validate the authenticity of Oncocytin?

Oncocytin should always be distributed in a sealed bottle with the company seal, and should only be purchased through certified company representatives