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Flashcards in Pharma Thyroid Deck (24):
0

Thyroid deprivation in early life

Cretinism
Dwarfism

1

Synthetic thyroid preparations

Levothyroxine
Liothyronine
Liotrix

2

Thyroid hormone clinical use

Obesity
Abnormal vaginal bleeding
Depression

3

Preparation of choice fir thyroid replacement

Synthetic levothyroxine

4

Liothyronine ae

Cardiotoxicity

5

Dessicated thyroid disadvantages

Protein antigenicity
Product instability

6

Thioamides

Ptu
Methimazole
Carbimazole

7

Methimazole

Ten times more potent than ptu

8

Metimazole prodrug

Carbimazole

9

Thiamazole

Metimazole na completely absorbed, once a day dosing

10

Congenital aplasia crutis??

Side effect of methimazole

11

Methimazole side effect ?

Maculopapular pruritic rash

12

Most dangerous complication of methimazole

Agranulocytosis

13

Anion inhibitors MOA

block uptake of iodide

14

Potassium perchlorate clinical use

Iodide induced hyperthyroidism

15

Jod basedow phenomenon

When iodides can induce hyperthyroidism (unpredictable effect)

16

Iodide main moa

Inhibit hormone release

17

What to use for radiation emergencies

Iodides

18

Iodide toxicity

Acneiform rash

19

Beta blockers without isa

Propanolol
Metoprolol
Atenolol

20

Diagnostic of hashimotos thyroiditis

Antithyroid antibodies

21

Levothyroxine dose

1.7 mcg per kg per day, OD

22

Thyrotoxicity

In elderly.. Atrial fibrillation and accelerated osteoporosis

23

Large doses of iodine inhibit iodide organification

Wolff Chaikoff block