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1

major involuntary, unconscious, autonomic portion of the nervous system
-contrasts in several ways with the somatic nervous system

ANS

2

– major pathway for information transmission from CNS to the involuntary effector tissues

Motor (efferent) portion of ANS

3

2 Major Subdivisions of ANS:

1. PANS
2. SANS

4

– semiautonomic part of the ANS located in the GI tract
-consists of myenteric plexus or plexus of Auerbach and the submucous plexus of plexus of Meissner

ENS

5

SYMPATHETIC (SANS) Preganglionic fibers originate from:

• Thoracic (T1-T12) segments of the cord
• Lumbar (L1-L5) segments of the cord

6

PARASYMPATHETIC (PANS) Preganglionic motor fibers originate from

• Cranial nerve nuclei III, VII, IX and X
• Sacral segments (S2-S4)

7

Sympathetic or para
Most of the ganglia are located in 2 paravertebral chains that lie along the spinal cord

SYMPATHETIC

8

Sympathetic or para
Preganglionic fibers are short and the postganglionic fibers are long

SYMPATHETIC

9

• Most of the ganglia are located in the organs innervated, most distant from the spinal cord

PARASYMPATHETIC

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• Preganglionic fibers are long and the postganglionic fibers are short

PARASYMPATHETIC

11


• A nerve ending that releases acetylcholine as the primary transmitter
• Also a synapse in which acetylcholine is the primary transmitter

CHOLINERGIC

12

primary transmitter in all autonomic ganglia and at the synapses between the parasympathetic ganglia and their effector cells

Ach

13

• All postganglionic parasympathetic fibers are

cholinergic

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• A few postganglionic sympathetic fibers are

cholinergic

15

• All preganglionic fibers are

cholinergic

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• Ach Synthesis Enzyme:

choline acetyltransferase

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Ach is synthesized from

Acetyl-coA+choline

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Rate-limiting step of Ach synthesis:

transport of choline into nerve terminal

19


• Inhibits transport/synthesis of ACh into the cell


HEMICHOLINIUM

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• Inhibits storage of ACh into the vesicle

VESAMICOL

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• Inhibits the release of Ach
• Prevents contraction of muscles

BOTULINUM TOXIN

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• A nerve ending that releases norepinephrine as the primary transmitter

ADRENERGIC

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• Also a synapse in which norepinephrine is the primary transmitter

ADRENERGIC

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• Most postganglionic sympathetic fibers are

adrenergic

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• Most postganglionic sympathetic fibers are adrenergic except for

sweat glands, thermoregulatory center, arrector pili

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• Adrenal cortex and medulla
• Ductless gland that functions as a ganglion
• Postganglionic fibers are cholinergic

ADRENAL GLAND

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• Inhibits the synthesis of NE




METYROSINE

28

• Inhibits the storage of NE
• Anti-hypertensive agent

RESERPINE

29

• Inhibits release of NE
• Used to lower blood pressure

GUANETHEDINE

30

• Inhibits metabolism of NE
• Vasoconstriction, higher BP

MAO I
Monoamine oxidase

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