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Pharmacology > Pharmacodynamics > Flashcards

Pharmacodynamics Flashcards

1
Q

Action of DRUG on the body

A

Pharmacodynamics

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2
Q

Maximal effect an agonist can produce if the dose is taken to very high levels

A

Maximal Efficacy (Emax)

determined by the NATURE of receptor

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3
Q

Denotes the amount of drug needed to produce a given effect

Dose that produces in 50% of the max effect

A

Potency (EC50

determined by the AFFINITY of the receptor

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4
Q

Drug concentration VS response

Graph of DOSE VS EFFECT

A

GRADED dose response

Emax
EC50

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5
Q

Drug concentration VS fraction POPULATION that responds at each dose against log of dose administered

Graph of DOSE VS response in a POPULATION

A

QUANTAL dose response

ED50 (therapeutic effect)
TD50 (toxic effect)
LD50 (lethal effect)

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6
Q

Measure which relates the DOSE of DRUG required to produced a DESIRED EFFECT to that which produces an undesired effect

A

Therapeutics Index = TD50/ED50

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7
Q

Drug capable of fully activating the effector system when it binds to the receptor

A

Full Agonist

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8
Q

Acts as inhibitor in the presence of an agonist

A

Partial Agonist

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9
Q

Blocks or dampens drug response in the presence of an agonist

A

Antagonist

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10
Q

Antagonist Classification

A

Pharmacologic

  • Competitive (reversible)
  • Non-competitive (irreversible)

Physiologic
Chemical

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11
Q

Bind to receptor very close to the agonist receptor site without activating the effector

A

Competitive or Reversible Antagonist

Atenolol and Salbutamol

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12
Q

Acts at an ALLOSTERIC STE of the receptor

Binds to different receptor

Alters the configuration of the agonist receptor

A

Non-competitive or Irreversible Antagonist

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13
Q

Inhibition by DIRECT interaction with a drug

Does NOT depend on interaction with receptors

A

Chemical Antagonists

Dimercaprol for lead poisoning
Pralidoxime for organophosphate poisoning

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14
Q

Binds to a different receptor that has the capacity of producing an effect opposite to that produced by the drug that it is antagonizing

A

Physiologic Antagonist

Histamine and Epinephrine

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15
Q

TACHYPHYLAXIS

frequent or continuous exposure to agonists often results in SHORT TERM DIMINUTION of the receptor response

A 
Metoclopramide
Ephedrine
Dobutamine
LSD
Calcitonin
Nitroglycerin
Nicotine
Hydralazine
Desmopressin
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16
Q

Idiosyncratic Reaction - SJS

A 
Sulfonamides
Phenytoin
Allopurinol
NSAIDS
Beta-lactams
17
Q

Idiosyncratic Reaction - Serum Sickness Like Rection

A

Cefaclor

Ceprozil

18
Q

Idiosyncratic Reaction - Drug Induced Lupus

A 
Procainamide
Hydralazine
Isoniazid
Methyldopa
Penicillamine
Minocycline
Chlorpromazine
19
Q

Idiosyncratic Reaction - Drug Induced Hepatitis

A 
Azathioprine
Antiretrovirals
Statins
NSAIDs
Phenytoin
Imipramine
Amiodarone
20
Q

Idiosyncratic Reaction - Aplastic Anemia, Agranulocytosis

A

Chloramphenicol
Dapsone
Clozapine
Carbimazole

Pharmacology (72 decks)

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