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Flashcards in Pharmacodynamics Deck (8):
1

The concentration required to bind 50% of the receptors

Kd

2

True or False.
Nalbuphine is a partial agonist to morphine.

True

3

Competitive or reversible antagonists cause a(n) ______________ shift of the dose-response curve.
Non-competitive or irreversible antagonists cause a(n) ______________ shift of the dose-response curve.

right
downward

4

What type of antagonism is present between the following?
a. norepinephrine and phenoxybenzamine
b. propranolol and isoproterenol
c. histamine and epinephrine
d. propranolol and thyroid hormone
e. dimercaprol for lead poisoning
f. pralidoxime for organophosphate poisoning

non-competitive
competitive
physiologic
physiologic
chemical
chemical

5

What concept is being referred to?
Frequent or continuous exposure to agonists often results in short-term diminution of the receptor response.

Tachyphylaxis

Think: tachy-response

6

What concept is being referred to?
Continuous activation may lead to depletion of essential substrates.

Tolerance

Think: tole-substrate

7

What drugs display tachyphylaxis? (9)

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Meroclopramide
Ephedrine
Dobutamine
LSD (lysergic acid diethylamide)
Calcitonin
Nitroglycerin
Nicotine
Hydralazine
Desmopressin

8

Idiosyncratic drug response:
_________________ with chloramphenicol
_________________ with allopurinol

aplastic anemia
cataracts

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