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Flashcards in Pharmacodynamics Deck (26)
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1

What makes a ligand receptor reaction specific

-Structure
-chemical
-solubility
-function of receptor

2

Name the types of drug receptors

-ligand gated
-voltage gated
-g-protein coupled
-IC nuclear

3

What effects prevent overstimulation of drug on rec.

-Tachyphylaxis
-Desensibilisation
-Inactivation
-Down-regulation
-Refractory

4

What is tachyphylaxis

repeated admin. causes decr. effect

5

What does a lower Kd mean

-tighter drug-rec. interaction
-higher affinity

6

What is the dissociation constant

-concentration of ligand at which 50% of the available receptors are occupied

7

Def. of Efficacy

The max. effect a drug can produce regardless of dose

8

Def. of potency

amount of drug needed to prod. a certain effect

9

Antagonists cause effect even when they're not bound t/f

f

10

How can a non-receptor antagonist act

-chemical antagonist can inactivate the agonist before it can bind
-physiological antagonist causes physiologic effect which is opposite to effect of agonist

11

Which effect does a competitive antagonist have on the potency and efficacy of the agonist

reduced potency but efficacy remains the same

12

Which effect does a non-competitive antagonist have on the potency and efficacy of the agonist

reduced efficacy

13

What is the relationship between the cc and the organsims response to a drug

response to drug is proportional to cc of recptors bound by it

14

Name the 2 types of dose-response relationships

graded and quantal

15

What are the possible reasons for a drug to be toxic

-genetic predisposition
-nonselective action
-inappropriate use or administration of the drug

16

name the types of adverse effects

-on target
-off target
-toxic metabolites
-prod. of harmful immune response

17

What could be possible on target adverse effects

-intended tissue intended receptor BUT
- inapropriate cc
- suboptimal kinetics

18

What can toxic metabolites cause

-lipid peroxidation - cell membrane damage
-prod. of reactive oxygen species
-depletion of glutathione - can result in cell death

19

What does the size of a drug matter in regards to immunoreactivity

- a drug molecule large enough can activate the immunesystem directly

20

Which general types of immune reactions are there

-hypersensitivity (allergic reactions)
-autoimmune reactions

21

Name the types of hypersensitivity

1 - immediate hypersensitvity
2 - antibody dependent cytotoxic hypersensitivity
3 - immune complex mediated hypersens.
4 - delayed type hypersensitivity

22

describe type 1 of the hypersensitivity reactions

-IgE prod. after exposure to AG
-subsequent exposure to AG leads to mast-cell degranulation
-release of inflammatory mediators - bronchoconst., vasodilatation, inflammation

23

describe type 2 of the hypersens. reactions

-drug binds to cells and is recognized by an AB
-lysis of cell

24

describe type 3 of hypersens. reaction

-ab are formed against soluble ag
- ag-ab complexes are then deposited in tissues

25

describe type 4 hypersens. reactions

-first exposure doesn't prod. response
-subsequent exposure triggers langerhans cells which activate t-cells
-cytokine storm

26

Prior exposure is required for each of the four hypersens types t/f

t