Flashcards in Pharmacogenomics II Deck (28):
what are the gene polymorphisms that affect pharmacokinetics?
solute carrier organic anion transporter 1B1
tamoxifen, codeine, and paroxetine are metabolized by what enzyme?
what drugs are metabolized by CYP2D6?
patients who are poor metabolizers for CYP2D6 will have what response to tamoxifen? why?
cannot be converted to active form
women with ER positive breast cancer need to be screened for what polymorphism?
what is the effect of CYP2D6 on codeine?
activation to active compound (morphine)
what is the effect of CYP2D6 on tamoxifen?
activation to active compound (4-OH tamoxifen)
what is the effect of CYP2D6 on paroxetine (SSRI)?
metabolism to less active compound
clopidogrel, omeprazole, and lansoprazole are metabolized by what enzyme?
which drugs are metabolized by CYP2C19 enzyme?
what is the effect of CYP2C19 on clopidogrel?
what might be a good alternative to clopidogrel therapy in patients with inactive CYP2C19 alleles?
what is the effect of CYP2C19 on omeprazole?
CYP2C19 poor metabolizers will have what omeperazole serum levels?
what enzyme is responsible for warfarin metabolism?
what is the effect of CYP2C9 on warfarin?
CYP2C9 poor metabolizers will show what levels of warfarin?
polymorphisms in what proteins affect 5-FU?
polymorphisms in what protein affects 6-MP?
what is the function of DPD?
reduces toxicity of 5-FU by inactivating it
decreased DPD leads to what? are these changes pharmacokinetic or pharmacodynamic?
increased adverse effects of 5-FU
what is the function of TPMT?
polymorphism causing a decrease in activity of SLC01B1 leads to what?
high levels of simvastatin
polymorphism at the ADRB2 gene has what affect on albuterol therapy?
polymorphisms in what proteins increases the risk of venous thromboembolisms with oral contraceptive use?
factor V leiden
individuals with a polymorphism in HLA-B 57:01 protein have a high risk of hypersensitivity (stevens johnson syndrome) when given what drug?
individuals with a polymorphism in HLA-B 57:01 protein have what response when given abacavir?
hypersensitivity (stevens johnson syndrome)