Pharmacogenomics II Flashcards Preview

Year 2 Pharmacology > Pharmacogenomics II > Flashcards

Flashcards in Pharmacogenomics II Deck (28):
1

what are the gene polymorphisms that affect pharmacokinetics?

metabolic enzymes:
CYP2D6
CYP2C19
CYP2C9
DPD
TPMT

drug transporters:
solute carrier organic anion transporter 1B1

2

tamoxifen, codeine, and paroxetine are metabolized by what enzyme?

CYP2D6

3

what drugs are metabolized by CYP2D6?

tamoxifen
codeine
paroxetine

4

patients who are poor metabolizers for CYP2D6 will have what response to tamoxifen? why?

low

cannot be converted to active form

5

women with ER positive breast cancer need to be screened for what polymorphism?

CYP2D6

6

what is the effect of CYP2D6 on codeine?

activation to active compound (morphine)

7

what is the effect of CYP2D6 on tamoxifen?

activation to active compound (4-OH tamoxifen)

8

what is the effect of CYP2D6 on paroxetine (SSRI)?

metabolism to less active compound

9

clopidogrel, omeprazole, and lansoprazole are metabolized by what enzyme?

CYP2C19

10

which drugs are metabolized by CYP2C19 enzyme?

clopidogrel
omeprazole
lansoprazole

11

what is the effect of CYP2C19 on clopidogrel?

activation

12

what might be a good alternative to clopidogrel therapy in patients with inactive CYP2C19 alleles?

asdf

13

what is the effect of CYP2C19 on omeprazole?

inactivation

14

CYP2C19 poor metabolizers will have what omeperazole serum levels?

high

15

what enzyme is responsible for warfarin metabolism?

CYP2C9

16

what is the effect of CYP2C9 on warfarin?

clears warfarin

17

CYP2C9 poor metabolizers will show what levels of warfarin?

high

18

polymorphisms in what proteins affect 5-FU?

DPD
TYMS

19

polymorphisms in what protein affects 6-MP?

TPMT

20

what is the function of DPD?

reduces toxicity of 5-FU by inactivating it

21

decreased DPD leads to what? are these changes pharmacokinetic or pharmacodynamic?

increased adverse effects of 5-FU

pharmacodynamic

22

what is the function of TPMT?

inactivates 6-MP

23

polymorphism causing a decrease in activity of SLC01B1 leads to what?

high levels of simvastatin

24

polymorphism at the ADRB2 gene has what affect on albuterol therapy?

decreased

25

polymorphisms in what proteins increases the risk of venous thromboembolisms with oral contraceptive use?

factor V leiden
prothrombin

26

individuals with a polymorphism in HLA-B 57:01 protein have a high risk of hypersensitivity (stevens johnson syndrome) when given what drug?

abacavir

27

individuals with a polymorphism in HLA-B 57:01 protein have what response when given abacavir?

hypersensitivity (stevens johnson syndrome)

28

alpha interferon therapy is used for what condition?

HCV

Decks in Year 2 Pharmacology Class (70):