pharmacokinetic features cholinomimetic drugs Flashcards Preview

► Med Misc 05 > pharmacokinetic features cholinomimetic drugs > Flashcards

Flashcards in pharmacokinetic features cholinomimetic drugs Deck (13):
1

Rapidly hydrolyzed by cholinesterase (ChE); duration of action 5–30 s; poor lipid solubility

Ach

2

Resistant to ChE; orally active, poor lipid solubility; duration of action 30 min to 2 h



Carbachol, Betanechol

3

Not an ester, good lipid solubility; duration of action 30 min to 2 h

Pilocarpine

4

Like pilocarpine; duration of action 1–6 h; high lipid solubility

Nicotine

5

Alcohol, quaternary amine, poor lipid solubility, not orally active; duration of action 5–15 min



edrophonium

6

Carbamate, quaternary amine, poor lipid solubility, orally active; duration of action 30 min to 2 h or more

neostigmine

7

Carbamate, tertiary amine, good lipid solubility, orally active; duration of action 30 min to 2 h

physostigmine

8

Carbamate, like neostigmine, but longer duration of action (4–8 h)

pyrodistigmine

9


Organophosphate, moderate lipid solubility; duration of action 2–7 days

echothiophosphate

10

Direct acting drugs that have both action on muscarinic and nicotinic

Ach and carbachol

11

A direact acting alkaloid drug that activates nicotinic receptors

Nicotine
Lobeline

12

Spectrum of action of bethanecol

Muscarinic

13

Organophosphate, high lipid solubility; duration of action 7–30 days

parathion

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