Pharmacokinetics

Question 1

pharmokinectic

Answer 1

component of drug actions, the dynamic factors that contribute to bioavailability

Question 2

bioavailability

Answer 2

amount of drug in the blood that is free to bind at target sites

Question 3

Factors that constitute the components of pharmacokinetic drug action

Answer 3

1.) Routes of administration

2.) Absorption and distribution

3.) Binding

4.) Inactivation

5.) Excretion

Question 4

enteral

Answer 4

drugs via oral , goes to the stomach

Question 5

parental

Answer 5

no oral administration, indirectly to the muscle

Question 6

absorption

Answer 6

the movement of the drug from the site of administration to the blood circulation

Question 7

intranasal administration

Answer 7

the drug moves very rapidly across a single epithelial cell layer into the bloodstream, avoiding first-pass liver metabolism and producing higher bioavailability than if given orally.

Question 8

the most important factor in determining plasma drug levels is

Answer 8

the rate of passage through cell membranes

Question 9

drug depots (silent receptors )

Answer 9

binding at inactive sites where no biological effect is initiated

includes plasma proteins, muscle, and fat

Question 10

drugs are eliminated via BLANk and metabolites are excreted

Answer 10

biotransformation

Question 11

2 types of biotransformation

Answer 11

type I = changes involve nonsynthetic modification of the drug molecule by oxidation, reduction, or hydrolysis

type II= modification are synthetic reaction that require the combination of the drug with some small molecule

Question 12

factors that influence the rate of biotransformation

Answer 12

enzyme induction
enzyme inhibition
drug competition