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Flashcards in Pharmacokinetics Deck (11):
1

What 4 factors influence the rate of diffusion of a drug?

Concentration gradient
Diffusion distance
Temperature
Any potential chemical reactions between drug and solute

2

What is plasma?

The fluid fraction remaining when cells are removed from blood. Aqueous solution.

3

Define 'compartments' and name 3 fluid compartments and 2 cellular compartments.

Compartments = How the body is divided, separated by tissue lipid rich barriers.

Fluid:
A) plasma 5L
B) interstitial 15L
C) intracellular 45L

Cellular tissue:
A) vessel rich viscera and muscle tissue
B) vessel poor fat stores/ subcutaneous tissue

4

Name 5 ways substances can move between compartments. Which is the most important?

1) Simple diffusion
2) Facilitated diffusion
3) Active transport
4) Through extracellular spaces
5) NON-IONIC DIFFUSION **

5

What influences the degree of ionisation of both weak acids and weak bases?

pH

6

What would be administered via IV?

Insulin, heparin, antibiotics, furosemide, antiarrythmics, inotropic support, sedation, anaesthesia, post operative analgesia.

7

Give 3 advantages of IV infusions over other methods of drug delivery?

1) bioavailability = 100%
2) steady state plasma levels maintained for as long as necessary
3) can work for drugs ineffective administered by other routes

8

Define bioavailability

-

9

If a drug was being administered at 'steady state' what would be occurring?

The infusion dosage = rate of elimination from plasma

10

What is pharmokinetics?

The effect of the body on drugs

11

What is pharmodynamics?

The effect of drugs on the body