Flashcards in Pharmacokinetics Deck (11):
What 4 factors influence the rate of diffusion of a drug?
Any potential chemical reactions between drug and solute
What is plasma?
The fluid fraction remaining when cells are removed from blood. Aqueous solution.
Define 'compartments' and name 3 fluid compartments and 2 cellular compartments.
Compartments = How the body is divided, separated by tissue lipid rich barriers.
A) plasma 5L
B) interstitial 15L
C) intracellular 45L
A) vessel rich viscera and muscle tissue
B) vessel poor fat stores/ subcutaneous tissue
Name 5 ways substances can move between compartments. Which is the most important?
1) Simple diffusion
2) Facilitated diffusion
3) Active transport
4) Through extracellular spaces
5) NON-IONIC DIFFUSION **
What influences the degree of ionisation of both weak acids and weak bases?
What would be administered via IV?
Insulin, heparin, antibiotics, furosemide, antiarrythmics, inotropic support, sedation, anaesthesia, post operative analgesia.
Give 3 advantages of IV infusions over other methods of drug delivery?
1) bioavailability = 100%
2) steady state plasma levels maintained for as long as necessary
3) can work for drugs ineffective administered by other routes
If a drug was being administered at 'steady state' what would be occurring?
The infusion dosage = rate of elimination from plasma
What is pharmokinetics?
The effect of the body on drugs