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Flashcards in Pharmacokinetics Deck (8):
1

Refers to the concentration f the drug at the receptor site

Effective drug concentration

2

The most important pharmacokinetic parameter to be considered in defining a rational steady state during dosage regimen
What is its formula using rate of elimination of drug and plasma drug concentration?

Clearance
= Rate of elimination of drug / Plasma drug concentration

3

True or False.
The steady state is reached in 4-5 half-lives of the drug.

True

4

Formula for half-life using Vd and Clearance
Formula for loading dose
Formula for maintenance dose
Formula for the corrected dose in renal impairment
Cockcroft-Gault equation

t1/2 = (0.693 x Vd) / Cl

LD = (Vd x desired plasma concentration) / bioavailability

MD = (Clearance x desired plasma concentration) / bioavailability

Corrected dose = Average dose x (Patient's creatinine clearance / 100 mL/min)

Creatinine clearance
= [(140-age) x Weight (kg)] / 72 x Serum creatinine (mg/dL)
In females, multiply answer by 0.85

5

Half-life and steady state concentration
1st:
2nd:
3rd:
4th:

50%
75%
87.5%
93.75%

6

Drugs notorious for SLE-like symptoms (3)

HIP
Hydralazine
Isoniazid
Procainamide

7

What should be given to a patient taking isoniazid to prevent peripheral neuropathy?

Vitamin B6

8

Drugs notorious for SJS (1)

Sulfonamides

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