Flashcards in Pharmacokinetics Deck (8):
Refers to the concentration f the drug at the receptor site
Effective drug concentration
The most important pharmacokinetic parameter to be considered in defining a rational steady state during dosage regimen
What is its formula using rate of elimination of drug and plasma drug concentration?
= Rate of elimination of drug / Plasma drug concentration
True or False.
The steady state is reached in 4-5 half-lives of the drug.
Formula for half-life using Vd and Clearance
Formula for loading dose
Formula for maintenance dose
Formula for the corrected dose in renal impairment
t1/2 = (0.693 x Vd) / Cl
LD = (Vd x desired plasma concentration) / bioavailability
MD = (Clearance x desired plasma concentration) / bioavailability
Corrected dose = Average dose x (Patient's creatinine clearance / 100 mL/min)
= [(140-age) x Weight (kg)] / 72 x Serum creatinine (mg/dL)
In females, multiply answer by 0.85
Half-life and steady state concentration
Drugs notorious for SLE-like symptoms (3)
What should be given to a patient taking isoniazid to prevent peripheral neuropathy?