Flashcards in Pharmacokinetics - Drug Metabolism and Excretion Deck (11)
Which type of metabolism has greater saturability?
What two substrates are needed for phase I metabolism?
Molecular oxygen and NADPH
Which type of metabolism is more inducible?
Phase I (alcoholics induce CYP2E1)
Zero-order kinetics are displayed in reactions ______.
that react a constant amount per time (regardless of change in concentration).
______ causes decreased clearance of Lipitor.
_______ is an enzyme inducer.
Antifungal agents (drugs ending in -azole) are typically ______.
Rifampin increases the clearance of _______.
Early neonatal levels of ______ enzymes are 50% - 70% of adult levels.
Warfarin targets ________.
vitamin K reductase