Pharmacokinetics - Drug Metabolism and Excretion Flashcards Preview

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Flashcards in Pharmacokinetics - Drug Metabolism and Excretion Deck (11):
1

Which type of metabolism has greater saturability?

Phase II

2

What two substrates are needed for phase I metabolism?

Molecular oxygen and NADPH

3

Which type of metabolism is more inducible?

Phase I (alcoholics induce CYP2E1)

4

Zero-order kinetics are displayed in reactions ______.

that react a constant amount per time (regardless of change in concentration).

5

______ causes decreased clearance of Lipitor.

Erythromycin

6

_______ is an enzyme inducer.

Phenobarbital

7

Antifungal agents (drugs ending in -azole) are typically ______.

enzyme inhibitors

8

Rifampin increases the clearance of _______.

oral contraceptives

9

Early neonatal levels of ______ enzymes are 50% - 70% of adult levels.

phase I

10

Warfarin targets ________.

vitamin K reductase

11

Older people have decreased ______ metabolism.

phase I

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