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Repro Exam 2 > Pharmacological Manipulation of Female Reproduction > Flashcards

Pharmacological Manipulation of Female Reproduction Flashcards

1
Q

Why would you want to manipulate the estrous cycle?

A
  1. improve reproductive efficiency
  2. assisted/advanced reproductive techniques
  3. improve management convenience/efficiency
  4. management of undesirable behavior
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2
Q

Name the 7 basic approaches to manipulating the estrous cycle

A
  1. mimic the CL by administering progesterone
  2. lyse the CL by administering a luteolytic drug
  3. induce ovulation of a mature follicle by causing an LH surge
  4. prevent cyclicity by suppressing the hypothalamo-pituitary axis
  5. induce cyclicity in an anestrus animal
  6. increase ovulation rate by administering FSH or FSH-like compounds
  7. various combinations of the above
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3
Q

How can you mimic the CL in cattle?

A

melengesterol acetate (MGA)
Syncro-Mate B
CIDR-B
PRID

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4
Q

How can you mimic the CL in sheep and goats?

A

MGA
progestagen impregnated sponges
CIDR-G

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5
Q

How do you mimic the CL in horses?

A

regumate (progestagen given orally or in feed)

injectable progesterone

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6
Q

How do you mimic the CL in bitches?

A

megestrol acetate (Ovaban)

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7
Q

What is required if you want to lyse the CL?

A

animals have to be cycling

the CL has to be at a responsive stage of development

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8
Q

How do you lyse the CL in cattle?

A

lutalyse (dinoprost)

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9
Q

How do you lyse the CL in sheep and goats?

A

lutalyse

estrumate

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10
Q

How do you lyse the CL in horses?

A

lutalyse

estrumate

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11
Q

How do you lyse the CL in sows?

A

must use a lysing drug in combination with something that lengthens luteal phase or provides an artificial CL

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12
Q

How can you induce ovulation?

A
  • supply GnRH or an analog and use the animals own LH

- use human chorionic gonadotropin that has long-lasting LH activity

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13
Q

How can you induce ovulation in cattle?

A

cystorelin or factrel (gonadorelins)

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14
Q

How can you induce ovulation in horses?

A

HCG

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15
Q

How can you induce ovulation in queens?

A

HCG

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16
Q

How can you suppress the hypothalamo-pituiary axis?

A

GnRH super agonists
GnRH antagonists
Mibolerone drops (anabolic steroid)

17
Q

How can you induce cyclicity in anestrus queens?

A

GnRH

FSH and HCG

18
Q

How can you induce cyclicity in anestrus bitches?

A

dopamine agonists

GnRH super agonists

19
Q

How can you increase ovulation rate?

A

higher total doses of FSH

20
Q

What are two other options for manipulating the estrous cycle?

A
  • melatonin implants to induce out of season cyclicity

- vaccination against androstenedione, which increases ovulation

Repro Exam 2 (9 decks)

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