Flashcards in Pharmacology 1 - Drug Eruptions (not finished) Deck (24):
What is a drug eruption?
An adverse drug reaction of the skin
What 2 factors play a role in deciding whether (and the time frame in which) a drug eruption will resolve when a drug is withdrawn?
Ability of drug to accumulate in tissue
1/2 life of drug
Example of a type 1 immunologically mediated drug eruption?
Example of a type 2 immunologically mediated drug eruption?
Pemphigus and pemphigoid
Example of a type 3 immunologically mediated drug eruption?
Example of a type 4 immunologically mediated drug eruption?
Are immunologically mediated drug eruptions dose dependent?
5 examples of non-immunological drug eruptions>
Atrophy from topical steroids
6 presentations of drug eruptions?
Exanthematous/ morbilliform/ maculopapular (synonymous) - most common (75-95%)
Papulosquamous/ pustular/ bullous
What does an Exanthematous/ morbilliform/ maculopapular rash look like?
A diffuse and symmetric eruption of erythematous macules/ small pupules
What is a papulosquamous rash?
Papules + scales
Are young adults or infants/ elderly more likely to get a drug eruption?
Are males or females more likely to get a drug eruption?
What features of penicillin make it more likely to cause a drug eruption? (2)
It is a haptem forming drug
What is a haptem?
A molecule that illicits an immune response only when attached to a large carrier
What 3 chemical features make a drug more likely to cause a drug eruption?
B lactam compounds
High molecular weight/ haptem forming drugs
Are mucous membranes usually affected in an Exanthematous/ morbilliform/ maculopapular drug eruption?
What type of hypersensitivity is an exanthematous drug eruption usually?
Usual onset time of an Exanthematous/ morbilliform/ maculopapular drug eruption after taking drug?
4 - 10 days
What features of an Exanthematous/ morbilliform/ maculopapular drug eruption rams indicate a potentially severe reaction? (3)
What drugs are associated with an Exanthematous/ morbilliform/ maculopapular drug eruption? (9)
What type of drug is phenytoin?
What type of drug is chloramphenicol?