Pharmacology 1 - Drug Eruptions (not finished) Flashcards Preview

2nd Year - Dermatology > Pharmacology 1 - Drug Eruptions (not finished) > Flashcards

Flashcards in Pharmacology 1 - Drug Eruptions (not finished) Deck (24):
1

What is a drug eruption?

An adverse drug reaction of the skin

2

What 2 factors play a role in deciding whether (and the time frame in which) a drug eruption will resolve when a drug is withdrawn?

Ability of drug to accumulate in tissue
1/2 life of drug

3

Example of a type 1 immunologically mediated drug eruption?

Urticaria

4

Example of a type 2 immunologically mediated drug eruption?

Pemphigus and pemphigoid

5

Example of a type 3 immunologically mediated drug eruption?

Purpura

6

Example of a type 4 immunologically mediated drug eruption?

Contact dermatitis

7

Are immunologically mediated drug eruptions dose dependent?

No

8

5 examples of non-immunological drug eruptions>

Drug-induced alopecia
Photo-toxicity
Skin erosion
Atrophy from topical steroids
Pigmentation
Many others

9

6 presentations of drug eruptions?

Exanthematous/ morbilliform/ maculopapular (synonymous) - most common (75-95%)
Urticarial (5-10%)
Papulosquamous/ pustular/ bullous
Pigmentation
Photosensitivity
Itch/ pain

10

What does an Exanthematous/ morbilliform/ maculopapular rash look like?

A diffuse and symmetric eruption of erythematous macules/ small pupules

11

What is a papulosquamous rash?

Papules + scales

12

Are young adults or infants/ elderly more likely to get a drug eruption?

Young adults

13

Are males or females more likely to get a drug eruption?

Females

14

What features of penicillin make it more likely to cause a drug eruption? (2)

B-lactam compounds
It is a haptem forming drug

15

What is a haptem?

A molecule that illicits an immune response only when attached to a large carrier

16

What 3 chemical features make a drug more likely to cause a drug eruption?

B lactam compounds
NSAIDs
High molecular weight/ haptem forming drugs

17

Are mucous membranes usually affected in an Exanthematous/ morbilliform/ maculopapular drug eruption?

Usually spared

18

What type of hypersensitivity is an exanthematous drug eruption usually?

Type 4

19

Usual onset time of an Exanthematous/ morbilliform/ maculopapular drug eruption after taking drug?

4 - 10 days

20

What features of an Exanthematous/ morbilliform/ maculopapular drug eruption rams indicate a potentially severe reaction? (3)

Blisters
Purpura
Necrosis

21

What drugs are associated with an Exanthematous/ morbilliform/ maculopapular drug eruption? (9)

Sulphonamide antibiotics
Penicillin
Chloramphenicol
Streptomycin
Erythromycin

Phenytoin
Carbamazepine

NSIADs
Allopurinol

22

What type of drug is phenytoin?

Anti-seizure drug

23

What type of drug is chloramphenicol?

Antibiotic

24

What type of drug is carbamazepine?

Anti-seizure drug