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Flashcards in Pharmacology Deck (68):
1

"-osin"

a1 selective blocker

2

Mirtazapine

a2 selective blocker

3

Garlic order

Arsenic

4

Arsenic antidote

Dimercaprol

5

Km is inversely proportional to

affinity of enzyme to its subtrate

6

Vmax is proportional to

enz conc.

7

In the line weaver burk plot, when the x intercept closer to zero, km

increases (affinity decreases)

8

what is common between irreverrible competitive and non-competitive

decreased Vmax and efficacy

9

formula for Vd

amount of drug in the body/plasma conc.

10

formula for CL

rate of elimintion of drug/plasma conc
or
Vd x elimination constant

11

formula for t 1/2

0.693xVd/CL

12

formula for loading and maitenance dose

Cp x Vd/F
Cp x CL/F

13

eg. of zero order kinetics

PEA
Phenytoin
Ethanol
Aspirin

14

acidic drugs example

phenobarbital methotrexate aspirin(salicylic acid) TCA (alkalinize ith bicarbonate)

15

basic drug example

amphetamine (acidify with ammonium chloride)

16

phase II metabolism

GAS
glucuronidation
Acetylation
Sulfation

17

eg. of acetylation drugs

isoniazid, dapsone, hydralzine, procainamide

18

partial agonists has less DASH than full agonist

efficacy

19

potency is related to

EC50

20

3 graphs of inhibition

competitive to right
non-competitive down
partial agonist low efficacy

21

eg. of small therapeutic index drugs

warfarin theophylline digoxin lithium

22

Ach N sites

somatic sk mm
all ganglia and adrenal medulla

23

Ach M sites

para: cardiac, sm. mm, gland cells, nerve terminals
symp: sweat glands

24

NE alpha beta sites

sympathetic:cardiac, sm. mm, gland cells, nerve terminals

25

D D1 sites

symp: renal vasculature, smooth muscle

26

alpha 1 action on vessels

vasoconstriction

27

beta 2 action on vessels

vasodilation

28

alpha 2 action

decreased sympathetic flow, insulin release, lipolysis, aques humor production
increased platelet aggregation

29

Ach M3 action: think about

AchE poisoing

30

HAV 1 M&M

Phospholipase C Protein kinase C

31

MAD2

Gi Adenyle Cyclase decresed cAMP, Protein kinase A

32

direct cholinomimetics

bethanechol, carbachol, methacholine, pilocarpine

33

Indirect cholino drugs

Edrophonium, physo, neo, pyrido
donepezil, galantamine, rivastigmine

34

Glycopyrrolate is a

muscarinic antagonists (pre-op to reduce airway secretions)

35

Oxybutynin is a

muscarinic antagonists (to reduce bladder spasm)

36

scopolamine what and indication (other drugs)

anti-muscarinic and motion sickness
(meclizine and diphendydrinate)

37

DOC for gardners pupil

physostigmine

38

atropine on heart rt

tachycardia

39

puffer fish, reef fish, dark meat fish toxins

tetrodotoxin
ciguatoxin
scombroid

40

dobutamine mech and indi

beta 1 more than beta 2
cardiogenic shock

41

isoproteronol receptor preference

beta 1=2

42

phenylephrine, methoxamine receptor preference

alpha 1 > 2

43

name indirect sympathomimetics

aphetamine cocaine ephedrine

44

sympatholytics

clonidine and a-methyl dopa

45

non-selective alpha beta antoganist

carvedilol labetalol

46

antidote: acetaminophen

n-acetyl cysteine

47

antidote: benzodiazepines

flumazenil

48

antidote: beta blockers

glucagon

49

antidote: heparin

protmaine sulphate

50

antidote: opoid

naloxone

51

antidote: organophosphate

atropine pralidoxime

52

antidote: methanol

fomepizole

53

antidote:streptokinase

epsilon amino caproic acid

54

drugs causing cutaneous flushing

VANC
vancomycin
adenosine
niacin
calcium channel blockers

55

drugs causing hypothyroidsm

lithium amiodarone sulphonamides

56

drugs causing a/c cholestatic jaundice

erythromycin

57

drugs causing hepatic necrosis

halophane, amatoxin, valproic acid acetaminophen
HAVAc

58

drug causing pancreatitis

didanoisine

59

drugs causing direct coombs + hemolytic anemia

methyl dopa and penicillin

60

drug causing thrombocytopenia

heparin

61

drugs causing megaloblastic anemia

pheytoin, methotrexate and sulph drugs

62

drugs causing fat redistribtuion

protease inhi and GC

63

drugs causing gingival hyperplasia

phenytoin cycloporine, CCB

64

drugs causing cinchoism

quinine

65

drugs causing DCM

anthracyclines (doxo and dauno)

66

inducers of p450

chronic alcohol, St johns wort, phenytoin, phenobarbital, nevirapine, carbamazepine, rifampin and greseiofulvin
phen-phen,pine-pine,pin and vin

67

substrates of p450

warfarin
theophylline
OCP
anti-epieptics

68

184_code for protein synthesis inhibitors antibiotics

buy AT 30 and CCEL at 50