Pharmacology Flashcards
(20 cards)
Which of the following statements is tre regarding drug metabolism *
A.Phase 1 reactions convert the parent drug to a more polar or more reactive product
B.Phase 2 reactions involve conjugation of subgroups
C.Drugs may undergo phase II metabolism before or after phase II
D.Hydrolysis is an example of a phase I reaction
E.All of the above
e
Cytochrome P450 inhibitor, EXCEPT
A.Cimetedine B.Ketoconazole C.Ritonavir D.Azithromycin E.None of the above
c
Partially activates nicotinic receptors, may be used to treat nicotine addiction *
A.Bethanecol B.Varenicline C.PIlocarpine D.Carbachol E. Edrophonium
a
Which of the following is a cholinergic antagonist used to treat Parkinson’s disease
A.Galantamine B.Rivastigmine C.Benztropine D.Tacrine E.Donepezil
c
Activates both β1 and β2 receptors
A.Isoproterenol B.Dobutamine C.Albuterol D.Propanolol E.Metropolol
d
Which of the following treatments of glaucoma, act by increasing outflow through the Canal of Schlemm
A.Pilocarpine B.Timolol C.Mannitol D.Epinephrine E.Latanoprost
a
Which of the following anti-hypertensives should be avoided during pregnancy?
A.Methyldopa B.Hydralazine C.Nifedepine D.Enalapril E.Labetalol
d
The following are known to cause gingival hyperplasia, EXCEPT
A.Nifedepine B.Verapamil C.Diltiazem D.Cyclosporine E.Phenytoin
c
In the treatment of angina pectoris, the combined use of a Nitrate and a β-Blocker or a Calcium channel blocker has no effect on which of the following factors? *
A.Heart rate B.Arterial pressure C.End-diastolic pressure D.Ejection time E.Net myocardial O2 requirement
d
Which of the following antiarrythmic drugs prolongsthe AP duraton
A.Disopyramide B.Lidocaine C.Tocainide D.Flecainide E.Phenytoin
b
Which of the following when given with statins increases the risk of myopathy and rhabdomyolysis?
A.Ezetimibe B.Gemfibrozil C.Niacin D.Cholestyramine E.Sitosterol
d
A newborn presents with cyanosis and shortness of breath, history also reveals that the mother is a known diabetic. Chest x-ray was done showing a cardio-mediastinal silhouette appearing as an “egg on a string”. Which of the following drugs is beneficial to the patient’s condition?
A.Indomethacin B.Ibuprofen C.Alprostadil D.Both A and B E.All of the above
a
The following statements are true, EXCEPT
A.Salmeterol increases asthma mortality when used alone
B.Ipatropium is more effective and less toxic than beta-agonists in patienst with COPD
C.Monteleukast has no bronchodilator action
D.Beta agonists are given as antidote for Theophylline overdose
E.Theophylline has a narrow therapeutic window
a
ntiplatelet drug that act by inhibiting phosphodiesterase III and increases cAMP in platelets and blood vessels
A.Abciximab B.Clopidogrel C.Aspirin D.Ticlopidine E.Cilostazol
c
Antiseizure drug used for Absence seizures, acts by decreasing Ca2+ currents (T-type) in the thalamus
A.Lamotrigine B.Valproic acid C.Topiramate D.Levetiracetam E.Ethosuximide
b
Which of the following is an example of an Atypical Antipsychotic?
A.Chlorpromazine B.Thioridazine C.Haloperidol D.Olanzapine E.Fluphenazine
b
Drug of choice for pregnant patients with Cushing’s syndrome
A.Aminoglutethimide B.Ketoconazole C.Metyraone D.Itraconazole E.Both B and D
b
Which of the following Antidiabetic agents has a Disulfiram effect?
A.Glipizide B.Chlorpropamide C.Pioglitazone D.Arcabose E.Metformin
a
Cilastin is paired with this drug to inhibit its renal metabolism
A.Imipenem B.Ertapenem C.Meropenem D.Doripenem E.Aztreonam
e
Rifampin derivative that is not absorbed in the GIT, and so is used for the prevention of hepatic encephalopathy and for treatment of traverler’s diarrhea
A.Rifampicin B.Rifabutin C.Rifapentine D.Rifaximine E.None of the above
a
