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Flashcards in PHARMACOLOGY Deck (20):
1

therapeutic ratio equation

max tolerated conc divided by min effective conc

2

why is a low therapeutic ratio bad

means there isnt much difference in an effective conc and a damaging conc = can be dangerous if you dont monitor it

3

what are the parasympathetic pre ganglionic neurons

ACh

4

what are the parasympathetic post ganglion neurones

ACh

5

what are the sympathetic pre ganglion neurones

ACh

6

what are the sympathetic post ganglion neurones

noradrenaline

7

which G protein is stimulated by M1

Gq

8

which G protein is stimulated by M2

Gi

9

which G protein is stimulated by M3

Gq

10

which G protein is stimulated by alpha1

Gq

11

which G protein is stimulated by alpha2

Gi

12

which G protein is stimulated by beta1

Gs

13

which G protein is stimulated by beta2

Gs

14

M1 = Gq =

increased phospholipase C = stomach acid secretion

15

M2 = Gi =

decreased adenyl cyclase = decreased heart rate

16

M3 = Gq =

increased phospholipase C = salivary gland secretion, bronchoconstriction, vasodilation

17

A1 = Gq =

increased adenyl cyclase = vasoconstriction

18

A2 = Gi =

decreased adenyl cyclase = decreased noradrenaline

19

B1 = Gs =

increased adenyl cyclase = increase heart rate

20

B2 = Gs =

increased adenyl cyclase = bronchodilation, vasoconstriction (but vasodilation of coronary vessels = blood gets back to heart)