Flashcards in Pharmacology - Drug Toxiciology I & II - Christine Stork-Medicis Deck (25):
Decreased bowel sounds;
Altered mental status;
Slow HR, BP down, temp down
What is the half life of Naloxone?
Mu/delta/kappa opioid receptor antagonist
Competitive inhibitor of mu, delta, kappa opioid
What is the toxidrome for benzodiazepines?
No respiratory depression if not mixed;
Mental status depression
Competitive non-selective benzodiazepine receptor antagonist
What are the symptoms of Stage I Acetaminophen toxicity?
Mild GI irritation
What are the symptoms of Stage II Acetaminophen toxicity?
LFT and renal fx abnormalities +/- RUQ pain
What are the symptoms of Stage III Acetaminophen toxicity?
Hepatic necrosis +/- renal failure
What are the symptoms of Stage IV Acetaminophen toxicity?
4 days to 2 weeks
Resolution of organ fx
What is the antidote for acetominophen poisoning?
Give within 8 hours of OD
Resupplies glutathione stores
What are signs of late Acetominophen toxicity?
Prothrombin time > 200s
Serum creatinine > 3.3
Blood pH 30
What toxidrome is being described?
No bowel sounds;
Dry flushed skin;
What ECG findings are common in tricyclic OD?
Widened QRS complex
What is the antidote for wide QRS complex, as seen with tricyclic antidepressant OD?
What is the antidote for anti-cholinergic OD?
Administer slowly to prevent seizures
When is using Physostigmine as an antidote contraindicated?
After TCA exposure - cases of asystole reported
Can use benzodiazepines to sedate the patient until a decision can be made.
Name the toxidrome:
Salivation, lacrimation, urination, defecation, Pupils contricted, CNS excitation, muscle fasciculations, breathing spasm
Muscarinic and nicotinic
What is the antidote for cholinergic toxidrome, as with heavy pesticide exposure?
Decreases atropine requirement
What is the antidote for methanol ingestions?
What is the antidote for ethylene glycol?
OD on Verapamil or Diltiazem can cause:
Bradycardia, Hypotension, Negative inotropy;