Flashcards in Pharmacology - Elderly Pharmacology - Sharon Brangman Deck (21):
T/F: The bioavailability of a drug does not change as we get older.
Lower body water means what for drug distribution in the elderly?
Lower Vd for hydrophilic drugs
Higher fat stores mean what for drug distribution in the elderly?
Higher Vd for lipophilic drugs
Metabolic clearance of a drug by the liver may be reduced in the elderly because
aging decreases liver blood flow, size, and mass
Drugs from what phase are preferred for use in the elderly?
Hepatic congestion from heart failure reduced the metabolism of what drug?
Smoking increases the clearance of what drug?
oxazepam is metabolized faster in older:
Men than older women
nefazodone concentrations are 50% higher in older:
women than younger women
In older adults, creatinine stays in the normal range, masking changes in what?
Why do Benzodiazepines cause more sedation and poorer psychomotor performance in older adults?
Likely caused by reduced clearance of the drug and resultant higher plasma level
Confusion in the elderly should be considered what before dementia?
What kinds of drugs are most responsible for causing ADEs in the elederly?
What are the most common adverse effects of drug-drug interactions in the elderly?
Acute renal failure
An ACEi and a diuretic together can cause what ADE?
An ACEi and potassium together can cause what ADE?
An antiarryythmic and a diuretic together can cause what ADE?
A benzodiazepine, an antidepressant, antipsychotic together can cause what ADE?
A calcium channel blocker and a diuretic or nitrate together can cause what ADE?
Digitalis and an antiarrhythmic together can cause what ADE?