Pharmacology - Elderly Pharmacology - Sharon Brangman Flashcards Preview

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Flashcards in Pharmacology - Elderly Pharmacology - Sharon Brangman Deck (21):
1

T/F: The bioavailability of a drug does not change as we get older.

True

2

Lower body water means what for drug distribution in the elderly?

Lower Vd for hydrophilic drugs

3

Higher fat stores mean what for drug distribution in the elderly?

Higher Vd for lipophilic drugs

4

Metabolic clearance of a drug by the liver may be reduced in the elderly because

aging decreases liver blood flow, size, and mass

5

Drugs from what phase are preferred for use in the elderly?

Phase II

6

Hepatic congestion from heart failure reduced the metabolism of what drug?

Warfarin

7

Smoking increases the clearance of what drug?

Theophylline

8

oxazepam is metabolized faster in older:

Men than older women

9

nefazodone concentrations are 50% higher in older:

women than younger women

10

In older adults, creatinine stays in the normal range, masking changes in what?

Creatinine clearance

11

Why do Benzodiazepines cause more sedation and poorer psychomotor performance in older adults?

Likely caused by reduced clearance of the drug and resultant higher plasma level

12

Confusion in the elderly should be considered what before dementia?

Drug interactions

13

What kinds of drugs are most responsible for causing ADEs in the elederly?

Cardiovascular drugs;
Psychotropics

14

What are the most common adverse effects of drug-drug interactions in the elderly?

Confusion
Cognitive impairment
Arterial hypotension
Acute renal failure

15

An ACEi and a diuretic together can cause what ADE?

Hypotension
Hyperkalemia

16

An ACEi and potassium together can cause what ADE?

Hyperkalemia

17

An antiarryythmic and a diuretic together can cause what ADE?

Electrolyte imbalance;
Arrhythmia

18

A benzodiazepine, an antidepressant, antipsychotic together can cause what ADE?

Confusion
Sedation
Falls

19

A calcium channel blocker and a diuretic or nitrate together can cause what ADE?

Hypotension

20

Digitalis and an antiarrhythmic together can cause what ADE?

Bradycardia
Arrhythmia

21

What are the best drugs to avoid in the elderly according to the Beers Criteria?

Benzodiazepines
Megestrol
Metclopramide
Non-cox NSAIDs
Nitrofurantoin
Antipsychotics
Insulin, sliding scale
Chloropropamide
Glyburide