Flashcards in Pharmacology: Katzung symphathomimetics Deck (53)
What are the two classes of symphathomimetics?
(1) direct acting
(2) indirect acting
What are the two classes of direct acting symphathomimetics?
(1) Alpha agonists
(2) Beta agonists
What are the two classes of indirect acting symphathomimetis?
(2) re-uptake inhibitors
What are the three subclasses of direct acting sympathomimetics?
(3) Non-catecholamine beta selective.
To what drug class do epinephrine, norepinephrine, Dopamine, isoproterenol, and dobutamine belong to?
They are catecholamines.
What is the mechanism of action for Epinephrine?
Epinephrine is an alpha 1 & 2, Beta 1,2, & 3 agonist.
What is the clinical use for epinephrine?
Epinephrine is used for anaphylaxis and hemostasis.
What are the major toxicities of epinephrine?
(5) pulmonary edema
What is the mechanism of action for Norepinephrine?
Alpha 1 & 2. Beta 1 agonist.
What are the clinical uses for Norepinephrine?
Neurogenic shock, last resort therapy in shock.
What are the adverse effects associated with norepinephrine?
(2) tissue necrosis
(3) excessive blood pressure increase
What is the mechanism of action for dopamine?
D1, Alpha1, Alpha 2, beta 1, beta 2, beta 3 agonist
What are the clinical uses for dopamine?
(2) renal shutdown
(3) occasionally heart failure
What are the adverse affects of dopamine?
(1) cardiovascular disturbances
What is the mechanism of action for isoproterenol?
Isoproterenol is a Beta 1, 2, & 3 agonist
What is the clinical use for isoproterenol?
isoproterenol is used for acute asthma by nebulizer.
What is the mechanism of action for dobutamine?
Dobutamine is a beta 1 agonist
What is the primary clinical use for dobutamine?
Dobutamine is a beta 1 agonist used in acute heart failure to increase cardiac output.
What is the mechanism of action for phenylephrine?
Phenylephrine is an alpha 1 alpha 2 agonist
What is the primary clinical use for phenylephrine?
(3) neurogenic hyotension.
What are the adverse affects associated with phenylephrine?
What is the mechanism of action for albuterol, metaproterenol, terbutaline, Salmeterol, and formoterol?
They are all Beta 2 agonists.
What is the primary clinical use for albuterol, metaproterenol, and terbutaline?
They are used for prompt onset for acute bronchospasm.
What are the adverse effects of the selective beta 2 agonists?
What are clinical uses for salmeterol, and formoterol?
Salmeterol, and formoterol are not useful in acute bronchospasm. They are used only with corticosteroids for prophylaxis. Slow onset, long action.
What are the three classes of indirect acting symphathomimetics?
What class of drugs do amphetamine, methamphetamine, and ephedrine belong to and what is their mechanism of action?
They are phenylisopropylamines. The MOA is that they displace stored catecholamines.
What are the clinical uses for Amphetamine and methamphetamine?
What are the adverse effects associated with Amphetamine and methamphetamine?
(1) High addiction liability