Pharmacology of Parathyroid & Metabolic Bone Disorders Flashcards Preview

Digestive, Endocrine, and Metabolic Systems > Pharmacology of Parathyroid & Metabolic Bone Disorders > Flashcards

Flashcards in Pharmacology of Parathyroid & Metabolic Bone Disorders Deck (18):
1

Cholecalciferol is the ____________ form of vitamin D.

precursor (i.e., without either hydroxyl group)

2

Vitamin D ___________ the release and production of PTH.

decreases

3

The major effect of estrogen on bone is ________________, though they also increase the number of osteocytes.

decreased number and activity of osteoclasts

4

Estrogens increase osteoblast production of ___________.

osteoprotegerin

5

In addition to antagonizing vitamin D, glucocorticoids also decrease bone density by _____________.

stimulating the overproduction of RANK and underproduction of osteoprotegerin

6

Non-pharmacologic therapy of osteoporosis should include _______________.

dietary intake of 1,500 mg of calcium and 1,000 IU of vitamin D; weight-bearing exercise; and smoking cessation

7

Denosumab is a _____________.

monoclonal antibody to the RANK-L

8

______________ bind to sites on bone and prevent bone resorption.

Bisphosphonates

9

Bisphosphonates are not recommended in those with _________________.

renal deficiency

10

When would you use SERMs (instead of bisphosphonates or estrogens)?

In a patient who can't tolerate bisphosphonates or is at risk of breast cancer (which estrogen can cause)

11

After a few days of treatment, "escape" can occur from use of ______________.

calcitonin

12

In which part of the nephron does PTH act to increase calcium resorption?

DCT

13

How does cinacalcet work?

It increases the sensitivity of the PTH CaSR, thus decreasing the release of PTH.

14

Calcitonin excess or deficiency is usually _____________.

asymptomatic

15

Teriparatide is a ____________ analog.

PTH (because PTH in intermittent doses actually promotes bone growth)

16

The main side effect of bisphosphonates is _______________.

esophagitis; because of this, instruct patients to take it with a lot of water and while standing upright

17

Bisphosphonates have a ________ half-life and are ___________ absorbed.

long; poorly

18

Sclerostin inhibits the ___________ pathway.

Wnt (thus antibodies to it promote bone growth)

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