Pharmacology of the Autonomic Nervous System Flashcards Preview

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Flashcards in Pharmacology of the Autonomic Nervous System Deck (21):
1

The thoracic and lumbar regions are..

Sympathetic 

2

Describe the location of the greater splanchnic nerve, celiac ganglion, lesser splanic nerve, and superior mesenteric ganglia 

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3

Compare the innervations of the somatic and autonomic nervous systems

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4

What happens when you over-activate the parasympathetic nervous system? 

Miosis

Salivation

Lacrimation

Perspiration

Diarrhoea

Bradycardia

Confusion

Coma

5

What do the actions of the parasympathetic include? 

- A decrease in the rate and force of heart beat

- Increased activity of the digestive system

- Emptying of the urinary bladder

- Erection of the genital (erectile) tissue

- Secretion of the salivary and lacrimal glands

 

6

Where are the cell bodies of the preganglionic neurons located? 

- In the brainstem

- And in S2-S4

7

Describe the effect of over activation of nicotinic receptors 

Miosis

Salivation

Lacrimation

Vomiting

Perspiration

Vomiting

Diarrhoea

Tachycardia

Hypertension

Tachypnea

Agitation

8

Describe nicotinic receptors

They are ligand gated ion channels

Work through depolarisation

Located: Nerve to nerve-ganglia &

Nerve to muscle 

9

Describe muscarinic receptors 

They are 7TM G protein coupled receptors

Work via ATP

Indirect

Depolarise, secretion contraction

not on motor end plate

Definition of muscarinic. : of, relating to, resembling, producing, or mediating the parasympathetic effects (such as a slowed heart rate and increased activity of smooth muscle) produced by muscarine. muscarinic receptors.

10

How does botox work? 

It prevents the release of the neurotransmitter acetylcholinefrom axon endings at the neuromuscular junction and thus causes flaccid paralysis

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11

How do cholinesterase inhibitors (Edrophonium, Neostigme, Pyridostigmine) work? 

They prevent the breakdown for cholinesterase. 

They block the breakdown of acetylcholine.

So give them atropine (muscarinic receptor antagonist) 

12

How does Atropine work? 

Muscarinic receptor antagonist 

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13

What are some muscarinic receptor drugs? 

Atropine, Scopolamine (Hyoscine) 

- Secretions, bradycardia (A only), gut hypermotility

- Hyoscine for motion sickness

Tropicamide - opthalmology 

14

What are some muscarinic receptor agonists? 

Pilocarpine - glaucoma 

15

What are the effects of noradrenergic neurons? 

- Tachycardia

- Hypertension

- Pallor

- Mydriasis

- Bronchodilation

16

How does adrenal medulla contribute to adrenaline? 

Has an enzyme that converts noradrenaline to adrenaline

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17

What is the one use of adrenaline? 

If we are HUNGRY

Adrenalaline released by adnreal medulla triggering gluconeogenesis 

18

What drugs affect presynaptic noradrenergic systems? 

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19

What are synaptic MAO inhibitors? 

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20

What drugs target B2 adrenoreceptors? 

Isoprenaline is a purely beta receptor agonist.

But Salbutamol is a bata-2 receptor agonist. (blocks ability of enzyme to break down the catecholamine) 

 

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21

What is alpha and beta selectivity? 

1. Alpha- usually ANS

2. Beta - husually humeral